Chronic treatment with nandrolone decanoate reduces left ventricular contractile response even when combined with strength training.

Introduction: The use of anabolic steroids is widely adopted for aesthetic purposes and sports performance. In supraphysiological doses, they can impair various physiological systems. However, we know little about their effects on the heart, especially when combined with strength training.

Clinical and Multiomic Features Differentiate Young Black and White Breast Cancer Cohorts Derived by Machine Learning Approaches.

Background: There are documented differences in Breast cancer (BrCA) presentations and outcomes between Black and White patients. In addition to molecular factors, socioeconomic, racial, and clinical factors result in disparities in outcomes for women in the United States. Using machine learning and unsupervised biclustering methods within a multiomics framework, here we sought to shed light on the biological and clinical underpinnings of observed differences between Black and White BrCA patients.

Association of meeting 24-hour movement guidelines with anxiety and depressive symptoms in adults.

There is growing evidence on the association between meeting the recommendations of isolated movement behaviors (physical activity, sedentary time, and sleep) with anxiety and depressive symptoms. However, the joint association of meeting the 24 h movement guidelines with anxiety and depressive symptoms is still unknown. The aim of this study was to analyze the association of meeting 24-hour movement guidelines with symptoms of anxiety and of depression in adults.

Exploring the uptake, accumulation, and distribution of nitrate in Swiss chard and spinach and their impact on food safety and human health.

Greenhouse vegetable production is often associated with the excessive use of nitrogen fertilizers and a high rate of nitrate accumulation. We evaluated the uptake, translocation, and accumulation of nitrate in chard and spinach under greenhouse conditions with optimal fertilization. The results revealed low levels of nitrate in the leachates and substrates (chard ˃ spinach).

Identification of fossil juniper seeds from Rancho La Brea (California, USA): drought and extirpation in the Late Pleistocene.

Juniperus spp. are keystone shrubs in western North America and important climatic indicators in paleo-records. However, a lack of taxonomic resolution among fossil species limits our ability to track past environmental changes.