The hypothesis that failure of histamine (Hi)-mediated inter and intracellular cell-cell communication may be involved in the control of cellular growth has been tested in leukaemia-bearing mice and fibrosarcoma-bearing rats. In all examined tissues of mice bearing leukaemia L1210 cells and rats bearing methylcholanthrene fibrosarcoma histamine content was higher than in controls. Tissues of fibrosarcoma-bearing rats more intensively metabolized 14C-Hi and oxidative pathway was predominant.
View Article and Find Full Text PDFArch Immunol Ther Exp (Warsz)
August 1983
The effect of an industrial agent--Fasavin E4, on isolated rat mast cells has been investigated. It was shown that Fasavin E4 released histamine in concentration dependent fashion. The reaction was neither calcium nor energy dependent.
View Article and Find Full Text PDFPol J Pharmacol Pharm
October 1981
The inflammatory effect of some compounds (polyglycolamines and polyglycolalcohols condensated with various number of ethylene oxide groups) used in textile industry were investigated as to their action on skin vascular permeability in rats and histamine release from rat peritoneal mast cells. The intradermal injection of tested agents caused the inflammatory skin reactions of various intensity depending on time, dose and chemical structure of agent used. It has been also shown that these properties of tested compounds were correlated with their histamine releasing activity and seemed to be dependent on their chemical structure, namely, the number of ethylene oxide groups in molecule.
View Article and Find Full Text PDFThe action of various salts of acetylcholine on isolated mast cells from Wistar and F1 hybrids of Wistar and August rats was investigated. None of the acetylcholine salts within the concentration range 10(-12) M to 10(-2) M was able to release histamine either from Wistar or from hybrid mast cells. Compound 48/80, used as a control, was active in both cases.
View Article and Find Full Text PDFArch Immunol Ther Exp (Warsz)
September 1981
The effect of various fluorides as to their ability to activate mast cells to subsequent secretory action of calcium have been investigated. The mechanism of action of both potassium and lithium fluoride conformed to a secretory process by being dependent on calcium and cellular metabolic energy. On the other hand, the action of ammonium fluoride seemed to be cytotoxic.
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