Publications by authors named "B Abril"
Background: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night-time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia.
Objectives: To identify the best candidates for receiving night-time only subcutaneous apomorphine infusion in routine care.
Methods: In this post-hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night-time only subcutaneous apomorphine infusion at the end of the study period or not.
HLA in isolated REM sleep behavior disorder and Lewy body dementia.
Ann Clin Transl Neurol
September 2023
Article Synopsis
- A study investigated the relationship between the human leukocyte antigen (HLA) locus and synucleinopathies, specifically Lewy body dementia (LBD) and isolated REM sleep behavior disorder (iRBD), which are linked to neuroinflammation.
- It was found that the HLA-DRB1*11:01 allele was significantly associated with iRBD, while several other alleles showed varying associations.
- The results imply that the HLA locus may have distinct roles depending on the type of synucleinopathy being examined.
Article Synopsis
- Sleep disturbances following ischaemic stroke can include issues like obstructive sleep apnea, insomnia, and restless legs syndrome, which may impact recovery.
- In a study involving 90 stroke patients, severe obstructive sleep apnea was assessed and participants were divided into two groups: one receiving continuous positive airway pressure (CPAP) treatment and the other receiving a placebo.
- Functional independence and other outcomes were measured at three months post-stroke, revealing no significant difference between CPAP and placebo in improving these scores, while factors like insomnia and decreased total sleep time correlated with poorer recovery.
Meat processing involves different transformations in the animal muscle after slaughtering, which results in changes in tenderness, aroma and colour, determining the quality of the final meat product. Enzymatic glycolysis, proteolysis and lipolysis play a key role in the conversion of muscle into meat. The accurate control of enzymatic reactions in meat muscle is complicated due to the numerous influential factors, as well as its low reaction rate.
View Article and Find Full Text PDFBackground: Obstructive sleep apnea syndrome is a common sleep-breathing disorder associated with adverse health outcomes including excessive daytime sleepiness, impaired quality of life and is well-established as a cardiovascular risk factor. Continuous positive airway pressure is the reference treatment, but its cardiovascular and metabolic benefits are still debated. Combined interventions aiming at improving patient's lifestyle behaviours are recommended in guidelines management of obstructive sleep apnea syndrome but adherence decreases over time and access to rehabilitation programmes is limited.
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