[Analysis of functional and biochemical changes in feline cerebral hemispheres after subchronic haloperidol administration].

Feline experiments have revealed that subchronic haloperidol causes asymmetric changes in the mesencephalic levels of dopamine and serotonin and impairs intrahemispheric balance between the dopaminergic and serotoninergic systems. At the same time the neuroleptic increases motor asymmetry, which appears in response to apomorphine, and changes the nature of interhemispheric relationships. The findings suggest that these changes may be one of the causes of extrapyramidal disorders associated with long-term use of the neuroleptic.

[The behavioral and neurochemical changes in rats caused by the subchronic administration of haloperidol].

Rat experiments showed that subchronic haloperidol enhanced or perverted motor asymmetry appearing in response to apomorphine, resulted in imbalance between the dopaminergic and serotoninergic systems and increased norepinephrine levels. It was concluded that intra- and interhemispheric imbalance might be one of the causes of extrapyramidal disorders associated with the long-term administration of the neuroleptic.

[Behavioral and EEG signs of the convulsive action of kynurenine and quinolinic acid in cats].

Administration of quinolinic acid but not L-kynurenine into the cat caudate nucleus was found to produce the appearance of epileptiform charges in the EEG with concomitant behavioral convulsions. A combination of quinolinic acid injections with systemic administration of penicillin resulted in the development of the status of myoclonic convulsions alternating with generalized tonicoclonic seizures. These states were eliminated by diazepam.

[Pharmacological analysis of the anticonvulsant action of kavinton].

In experiments on rats it was found that cavinton administered in doses of 1-30 mg/kg exerted a distinct dose-dependent anticonvulsant effect, according to the test of maximal electroshock, not less than that of phenobarbital, difenin and carbamazepine. Combined use of cavinton and these drugs potentiated its anticonvulsant action. The involvement of noradrenergic systems, in particular, alpha 1-adrenoceptors, in the anticonvulsant effect of cavinton is suggested.

[Complex approach to evaluating the antipsychotic properties of neuroleptics modeled on fenamine sterotypy in cats].

It was shown that the ability of neuroleptics to cause the high-amplitude wave bursts in sensorimotor cortex in cats with phenamine stereotypy may indicate antipsychotic properties of the drugs whereas suppression of motor automatism largely testifies to their extrapyramidal effects.