Maximizing similarity: Using correlation coefficients to calibrate kinetic parameters in population balance models.

Crystallization plays a crucial role as a separation and purification technique, particularly in the chemical and pharmaceutical industries. By adjusting process parameters, the productivity, product quality, and efficiency of downstream processes can be improved. In complex processes, model-based design becomes invaluable.

Complete Skin Clearance is Associated with the Greatest Benefits to Health-Related Quality of Life and Perceived Symptoms for Patients with Psoriasis.

Introduction: With newer biologics, the achievement of complete skin clearance has become an attainable treatment goal for patients with plaque psoriasis. We evaluate how improvements in Psoriasis Area and Severity Index (PASI) responses, particularly at incremental improvements approaching complete skin clearance (PASI 100), translate into improvements in health-related quality of life (HRQoL) and patient-perceived symptoms.

Methods: Data from the BE RADIANT phase 3b trial (NCT03536884) and its open-label extension (OLE), pooled across all study visits and treatments over 16 weeks (randomised patients) and 2 years (patients entering the OLE), were analysed using mixed-effects logistic regression models.

Effect of active and passive techniques used in thromboembolic prophylaxis on venous flow velocity in the post-procedure period.

Introduction: Studies have shown that using mechanical thromboembolic prophylaxis methods speeds up venous flow and decreases stasis. These studies examine the post-intervention period of 1-10 min. The length of the effect of procedures to raise venous flow velocity cannot be determined by clinical trials.

Improving the potential of paraCEST through magnetic-coupling induced line sharpening.

Magnetic coupling between paramagnetic centers is a crucial phenomenon in the design of efficient MRI contrast agents. In this study, we investigate the paraCEST properties and magnetic coupling effects of a novel homodinuclear Ni(ii) complex, 1, containing a Robson type macrocyclic ligand. A thorough analysis of the complex's electronic and magnetic properties revealed that the magnetic coupling effect reduces the transverse relaxation rate and enhances the sharpness of the proton resonances, leading to enhanced CEST efficiency.