JAK2 p.R564 germ line variants associated with hereditary thrombocythemia and hematologic neoplasms.

The Janus kinase 2 (JAK2) V617F mutation activates the transcription pathway and has been well-characterized as a driver of myeloproliferative neoplasms (MPNs). Recently, there has been a heightened interest in understanding germline predisposition to hematological malignancies including MPN, including several reports of familial MPN. Here, we retrospectively analyzed medical records and data from genetic testing to describe twelve patients with germline variants at amino acid position 564 of JAK2.

an open-source cognitive neuroscience toolkit for freely behaving nonhuman primates.

Unlabelled: Nonhuman primates (NHPs) are pivotal for unlocking the complexities of human cognition, yet traditional cognitive studies remain constrained to specialized laboratories. To revolutionize this paradigm, we present : an open-source, scalable in-cage platform tailored for freely behaving experiments in small primate species such as the common marmoset ( ). includes modular operant chambers that operate autonomously and integrate seamlessly with home cages, eliminating human intervention.

The Europa Imaging System (EIS) Investigation.

The Europa Imaging System (EIS) consists of a Narrow-Angle Camera (NAC) and a Wide-Angle Camera (WAC) that are designed to work together to address high-priority science objectives regarding Europa's geology, composition, and the nature of its ice shell. EIS accommodates variable geometry and illumination during rapid, low-altitude flybys with both framing and pushbroom imaging capability using rapid-readout, 8-megapixel (4k × 2k) detectors. Color observations are acquired using pushbroom imaging with up to six broadband filters.

Correction: "We are pleading for the government to do more": Road user perspectives on the magnitude, contributing factors, and potential solutions to road traffic injuries and deaths in Ghana.

[This corrects the article DOI: 10.1371/journal.pone.

BioRT-HBV 1.0: A Biogeochemical Reactive Transport Model at the Watershed Scale.

Reactive Transport Models (RTMs) are essential tools for understanding and predicting intertwined ecohydrological and biogeochemical processes on land and in rivers. While traditional RTMs have focused primarily on subsurface processes, recent watershed-scale RTMs have integrated ecohydrological and biogeochemical interactions between surface and subsurface. These emergent, watershed-scale RTMs are often spatially explicit and require extensive data, computational power, and computational expertise.