Publications by authors named "B A See"

Article Synopsis
  • Metastasis in cancer is linked to a process called epithelial-to-mesenchymal transition (EMT), which involves complex gene networks that can potentially be disrupted for therapeutic benefits.
  • Researchers identified key hub genes, particularly YWHAG, which is crucial in various human cancers and regulates responses during EMT by enhancing cellular protection against oxidative stress through autophagy.
  • YWHAG deficiency leads to increased oxidative stress, slower EMT, and cell death, while high YWHAG levels correlate with greater metastasis and improved survival in tumor models, suggesting its potential as a target for cancer treatment.
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Background: Aircrew are exposed to environmental pressure changes. In the Republic of Singapore Air Force (RSAF), applicants assessed to be at intermediate risk of otic barotrauma undergo a hypobaric chamber assessment ["trial of chamber" (TOC)] to functionally evaluate their suitability for military aircrew vocations.

Aims: To identify factors associated with TOC failure among applicants with otorhinolaryngological conditions.

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The primary somatosensory cortex (S1) is a region often targeted for input via somatosensory neuroprosthesis as tactile and proprioception are represented in S1. How this information is represented is an ongoing area of research. Neural signals are high-dimensional, making accurate models for decoding a significant challenge.

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Graves' Disease (GD) is a common cause of hyperthyroidism. Although definitive treatment with radioactive iodine (RAI) is preferred for military aircrew, there are cultural and individual differences in receptivity toward RAI, and clinical guidelines that recommend antithyroid drugs (ATD) as the first line therapy. We examined a case series of Republic of Singapore Air Force (RSAF) aviators with GD treated with ATD and the impact of their condition on aeromedical disposition.

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Aim: The long-term stress, anxiety and job burnout experienced by healthcare workers (HCWs) are important to consider as the novel coronavirus disease (COVID-19) pandemic stresses healthcare systems globally. The primary objective was to examine the changes in the proportion of HCWs reporting stress, anxiety, and job burnout over six months during the peak of the pandemic in Singapore. The secondary objective was to examine the extent that objective job characteristics, HCW-perceived job factors, and HCW personal resources were associated with stress, anxiety, and job burnout.

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