Publications by authors named "B A Schroeder"
Article Synopsis
- Indigenous maize varieties from eastern North America have significantly influenced breeding programs, but their origins remain unclear.
- Paleogenomic studies trace maize's journey to this region, indicating multiple migrations from Mexico, especially towards the northern U.S., including a notable path from the Southwest.
- Analysis shows that ancient Ozark maize specimens exhibit a unique wx1 gene linked to starch metabolism, demonstrating how selective pressures shaped maize domestication and connecting these varieties to the Northern Flints, vital for today's commercial maize.
Chimeric antigen receptor (CAR)-T cell products, classified as Advanced Therapy Medicinal Products (ATMPs), have shown promising outcomes in cancer immunotherapy. The quality of raw and starting materials used in manufacturing is critical to ensure the efficacy and safety of CAR-T cell products and depends primarily on the selection of the right materials and the right suppliers. It is essential to consider a long-term strategy when selecting raw and starting materials to prevent delays in the supply of innovative, high-quality, and safe therapies to patients.
View Article and Find Full Text PDFPurpose: Precision therapies and immunotherapies have revolutionized cancer care, with novel genomic biomarker-associated therapies being introduced into clinical practice rapidly, resulting in notable gains in patient survival. Despite this, there is significant variability in the utilization of tumor molecular profiling that spans the timing of test ordering, comprehensiveness of gene panels, and clinical decision support through therapy and trial recommendations.
Methods: To standardize testing, we designed a pathologist-directed test ordering system at the time of diagnosis using a 523-gene DNA/RNA hybrid comprehensive genomic profiling (CGP) panel and extensive clinical decision support tools.
Purpose: Targeted therapy development in soft tissue sarcoma (STS) has been burdened by the heterogeneity of this group of rare tumors. B7 homolog 3 protein (B7-H3) is a molecule in the same family as programmed death-ligand 1 (PD-L1). It has limited expression in noncancerous tissues and is overexpressed in many cancers, making it an attractive target for cancer therapy, and clinical trials targeting B7-H3 are actively underway.
View Article and Find Full Text PDFArticle Synopsis
- - Blending polyborosiloxane (PBS), an elastomer with unique viscoelastomeric properties, with organic semiconducting polymers can enhance the flexibility of wearable electronics.
- - The research examines the compatibility of two distinct PBS elastomers with poly(3-hexylthiophene) (P3HT), highlighting that one shows better blend compatibility due to varying crosslinking densities.
- - Detailed rheological experiments are conducted to investigate the viscoelastic properties and relaxation processes of the PBS:P3HT blends, focusing on the formation of P3HT crystallites within the material.