Evaluation of the preserving efficacy of lubricant eye drops with a novel preservative system.

Products provided in multidose containers must be adequately preserved in order to prevent contamination during repeated use. The aim of this study was to evaluate the ability of a lubricant eye drop formulation without traditional preservatives to control and prevent contamination under extreme microbial conditions. Bottles of a new lubricant eye drop with a novel preservative system (SYSTANE FREE Lubricant Eye Drops, Alcon Laboratories, Inc.

Biocide uptake in contact lenses and loss of fungicidal activity during storage of contact lenses.

Purpose: With recent outbreaks of Fusarium keratitis related to contact lens wear, studies were conducted to determine the biocide uptake during lens storage, and the resulting effect on antifungal activity of related products.

Methods: ACUVUE 2 (etafilcon A) soft, hydrophilic contact lenses (group IV) were soaked from 1 hour to 7 days in OPTI-FREE Express and OPTI-FREE RepleniSH multipurpose disinfecting solutions with POLYQUAD (polyquaternium-1) and ALDOX (myristamidopropyl dimethylamine) biocides and multipurpose solutions, Bausch & Lomb ReNu with MoistureLoc (Alexidine), ReNu MultiPlus (polyhexamethylene biguanide [PHMB]), and AMO Complete MoisturePLUS (PHMB). Storage solutions were tested to evaluate the effect of preservative uptake on the residual biocide activity against Fusarium solani.

Contribution of regimen steps to disinfection of hydrophilic contact lenses.

The effect of regimen steps on overall performance of contact lens disinfection processes was evaluated. Hydrophilic lenses were inoculated with Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Candida albicans, or Fusarium solani. Contributions of regimen steps and rinse volumes to disinfection abilities of OPTI-FREE EXPRESS, Solo-care Plus (Ciba Vision), Complete (Allergan), and ReNu MultiPlus (Bausch & Lomb) multi-purpose solutions were examined.

Anatomy of a regimen: consideration of multipurpose solutions during non-compliant use.

Consumers are often non-compliant with instructions for contact lens care products. This study explores the antimicrobial capacity of multipurpose solutions using variable use conditions. Opti-Free Express (Alcon) Multi-Purpose Disinfecting Solution with Polyquad (Alcon) and Aldox (Alcon) antimicrobial system and products containing PHMB (ReNu MultiPlus, Solo-care, and Complete multipurpose solutions) were evaluated.

Overview of the potency of moxifloxacin ophthalmic solution 0.5% (VIGAMOX).

Antibiotics have been the mainstay of therapy for infectious diseases since their origins in the 1940s. As microorganisms changed and resistance developed, more advanced antibiotics were ultimately needed to provide adequate coverage and spectrum. By selecting optimal antibiotics and dosing regimens, clinicians can avoid treatment failures and adverse events and can help prevent the emergence of further antibiotic resistance.