Publications by authors named "B A S Messiha"

Purpose: Among the most undesirable effects that lead to the restriction of doxorubicin (DOX) use in chemotherapy is kidney damage. This research aimed to assess the possible defenses against DOX-induced nephrotoxicity offered by oxyresveratrol (ORES) and/or dapagliflozin (DAPA).

Methods: Five groups of eight male Swiss albino rats each were created from a total of sixty-four.

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Article Synopsis
  • The study investigates the protective effects of lixisenatide (LX) and ticagrelor (TC) on diabetic nephropathy in rats with type 2 diabetes mellitus (T2DM), highlighting their antioxidant and anti-inflammatory properties.
  • Researchers induced T2DM in rats through a high-fat diet and an injection of streptozotocin, then treated them with LX, TC, or both over 4 weeks.
  • The results showed that both drugs improved kidney function and reduced injury markers, with the combined treatment yielding the most significant benefits by activating key antioxidant pathways and reducing inflammation in kidney tissues.*
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Antioxidants given concurrently with chemotherapy offer an effective strategy for reducing the negative effects of the drug. One remaining obstacle to the use of doxorubicin (DOX) in chemotherapy is cardiotoxicity. Using vitamin E (Vit.

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Background: Torsion of the spermatic cord is a hazardous and common urologic issue. The current work evaluates the possible protective effect of pregabalin (PGB) and xanthenone (XAN) in testicular ischemia/reperfusion injury induced by testicular torsion/detorsion in rats.

Materials And Methods: Seven groups of adult male Wistar albino rats were allocated randomly into seven groups, namely, sham control, torsion/detorsion (T/D), PGB 50 mg/kg, PGB 100 mg/kg, XAN 1 mg/kg, XAN 2 mg/kg, and PGB 50 mg/kg plus XAN 1 mg/kg groups.

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In this study, we hypothesized that lixisenatide (LIX) and ticagrelor (TIC) could have a protective effect against type 2 diabetes mellitus (T2DM)-induced vascular damage. Furthermore, we explored the possible additional protective effect of co-administering LIX and TIC in the treatment regimen. 50 male rats were divided into five groups, each comprising 10 rats: C (control), D (T2DM rats), D + LIX (T2DM rats treated with LIX for 4 weeks), D + TIC (T2DM rats treated with TIC for 4 weeks), and D + LIX + TIC (T2DM rats treated with LIX + TIC for 4 weeks).

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