Publications by authors named "B A Reinhardt"
This paper describes a synthetic aperture sonar (SAS) dataset collected in-air consisting of four types of targets in four environments of different complexity. The in-air laboratory based experiments produced data with a level of fidelity and ground truth accuracy that is not easily attainable in data collected underwater. The range of complexity, high level of data fidelity, and accurate ground truth provides a rich dataset with acoustic features on multiple scales.
View Article and Find Full Text PDFBackground: Paclitaxel is an antineoplastic agent used to treat breast, lung, endometrial, cervical, pancreatic, sarcoma, and thymoma cancer. However, drugs that induce, inhibit, or are substrates of cytochrome P450 (CYP) isoenzymes 2C8 or 3A4 may alter the metabolism of paclitaxel, potentially impacting its effectiveness. The purposes of this study are to provide an overview of paclitaxel use, identify potential drugs that interact with paclitaxel, and describe their clinical manifestations.
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- Measurement of CMV DNA in various specimens like bronchoalveolar lavages, intestinal biopsies, and urine is increasingly used for diagnosing CMV-related diseases, but many existing PCR tests are not validated for these samples.
- A new laboratory-developed test called Alinity LDT was evaluated, showing high reliability and good agreement compared to another test (RealTie LDT), with a high Pearson's correlation coefficient (r = 0.92) across different specimen types.
- The study indicates that Alinity LDT could improve patient management with rapid reporting of results, addressing important health concerns such as morbidity in transplant recipients and complications from congenital CMV infections.
Unlabelled: Bone marrow vascular endothelial cells (BM EC) regulate multiple myeloma pathogenesis. Identification of the mechanisms underlying this interaction could lead to the development of improved strategies for treating multiple myeloma. Here, we performed a transcriptomic analysis of human ECs with high capacity to promote multiple myeloma growth, revealing overexpression of the receptor tyrosine kinases, EPHB1 and EPHB4, in multiple myeloma-supportive ECs.
View Article and Find Full Text PDFBackground: Cycle threshold (Ct) values from SARS-CoV-2 nucleic acid amplification tests have been used to estimate viral load for treatment decisions. Additionally, there is a need for high-throughput testing, consolidating a variety of assays on one random-access analyzer.
Objectives: In this study, the clinical performance of the Alinity m SARS-CoV-2, RealTie SARS-CoV-2, and GeneXpert Xpress SARS-CoV-2/Flu/RSV assays was assessed.