Biomimetic niosomal versus liposomal nanoparticle-based aspirin injection for treating stroke and myocardial infarction.

In this work, we are comparing biomimetic niosomal nanoparticles (BNNs) with biomimetic liposomal nanoparticles (BLNs) and studying their drug carrier properties. A-BNNs and A-BLNs are prepared by lipid hydration method and characterized using DLS for size and zeta potential analysis, surface morphology by SEM, structural details by TEM, crystallinity and phase change by XRD, thermodynamic properties by DSC, TGA and DTGA, drug carrier properties by entrapment efficiency, drug release studies by open-end tube method and its mechanistic assessment by fitting with various models such as zero order, first order, Higuchi and Korsmeyer-Peppas models. The A-BNNs had an average size of 157.

Barcoding Notch signaling in the developing brain.

Developmental signaling inputs are fundamental for shaping cell fates and behavior. However, traditional fluorescent-based signaling reporters have limitations in scalability and molecular resolution of cell types. We present SABER-seq, a CRISPR-Cas molecular recorder that stores transient developmental signaling cues as permanent mutations in cellular genomes for deconstruction at later stages via single-cell transcriptomics.

A Multifunctional MXene/PVA Hydrogel as a Continuous Ionic Thermoelectric Generator and a Strain/Temperature Sensor.

This research reports a continuous output ionic thermoelectric (i-TE) system based on MXene/PVA (polyvinyl alcohol) hydrogel, by utilizing thermo-diffusion of Cu and Cl ions and the redox reaction involving Cu/Cu at the electrode interfaces. The thermopower of the i-TE system can be independently tuned to a value of -3.13 mVK by adjusting the ion diffusivity via MXene (TiCT).