Publications by authors named "B A O'Rourke"

Background: Aviation noise policy in the United States is decades old and has not kept up with the science on the adverse effects of chronic noise exposure. New aviation noise policies are needed for the 21 century, respecting the lived experience of affected communities. Existing surveys have reported adverse impacts from aviation noise but more information is needed to understand the factors that contribute to those impacts.

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Myotonia congenita is a hereditary, non-dystrophic skeletal muscle disorder associated with muscle stiffness due to delayed muscle relaxation after contraction. We review myotonia congenita in domesticated animals and humans and investigated suspected myotonia congenita in a flock of Merino sheep in Australia. In 2020, a property in New South Wales reported a four-year history of lambs that would fall on disturbance before rapidly recovering, with 13 affected sheep identified in 2020.

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Article Synopsis
  • * This study examines the impact of p38 MAPK inhibition using SB203580 in a guinea pig model, comparing untreated HF rats to those treated with SB203580 and controls, and assessing cardiac function via echocardiography and proteomic analysis.
  • * Results show that SB203580 treatment helps maintain cardiac function in HF by protecting critical proteins and reducing oxidative stress, indicating a potential therapeutic pathway for improving heart health in HF patients.
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Pulmonary hypoplasia with anasarca, or hydrops fetalis, is characterized by stillbirth, diffuse oedema, and generalized lymph node hypoplasia. The enlarged fetus frequently causes dystocia. The disease has been reported in cattle and sheep as an inherited condition with a recessive mode of inheritance.

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Lissencephaly and cerebellar hypoplasia (LCH) represents a spectrum of congenital developmental malformations of the cerebral cortex and cerebellum, mostly occurring as inherited conditions caused by variants in an increasingly recognized number of genes. LCH has been identified in three Dorset-cross lambs with congenital neurological signs in Australia. Lambs were unable to walk and had reduced vision, and one lamb developed a hypermetric gait and intention tremors.

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