Publications by authors named "B A O'Donnell"
Hypoparathyroidism (hypoPTH), sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant condition with approximately 200 cases published. HDR syndrome is caused by variants of GATA binding protein 3 gene (), which encodes a transcription factor, with multiple types of variants reported. We present the case of a 76-year-old woman who was diagnosed with hypoPTH when she was aged 40 years and transferred care to our institution.
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- Millions of tonnes of plastic and glass waste accumulate globally, predominantly ending up in landfills, highlighting the need for better recycling methods.
- This study explores using recycled glass fines incorporated in a high-density polyethylene (HDPE) matrix, conducting laboratory tests to optimize manufacturing conditions and composite design.
- The research identifies an ideal formulation that enhances the mechanical properties of the composites, showing significant improvements in strength due to strong hydrogen bonding, paving the way for sustainable use of waste materials in structural applications.
In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correlation between PANX1 mRNA and core Hippo components, Yes-associated protein 1 [YAP], Transcriptional coactivator with PDZ-binding motif [TAZ], and Hippo scaffold, Ras GTPase-activating-like protein IQGAP1 [IQGAP1], in invasive cutaneous melanoma and breast carcinoma. Furthermore, we demonstrated that PANX1 expression is upregulated in invasive melanoma cell lines and is associated with increased YAP protein levels.
View Article and Find Full Text PDFOrbital Cellulitis Secondary to Dacryocystitis: A Case Series and Literature Review.
Ophthalmic Plast Reconstr Surg
December 2024
Article Synopsis
- This study focused on identifying risk factors and management outcomes for patients with orbital cellulitis stemming from dacryocystitis, analyzing a group of 18 patients.
- The majority of patients (56% female, mean age 62) experienced reduced visual acuity, but most showed improvement after treatment, with acute intervention helping in resolving acute cellulitis.
- Key findings suggested that recurrent dacryocystitis and the presence of dacryoliths are significant risk factors, while immunosuppression worsens prognosis; successful long-term resolution typically requires dacryocystorhinostomy.
Pannexin (PANX) channels are present in skin and facilitate the movement of signalling molecules during cellular communication. PANX1 and PANX3 function in skin homeostasis and keratinocyte differentiation but were previously reduced in a small cohort of human cutaneous squamous cell carcinoma (cSCC) tumours compared to normal epidermis. In our study we used SCC-13 cells, limited publicly available RNA-seq data and a larger cohort of cSCC patient-matched samples to analyse PANX1 and PANX3 expression and determine the association between their dysregulation and the malignant properties of cSCC.
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