Phytocorrection of Age-Related Changes in the Composition of Blood Plasma, Lymph, and Interstitial Fluid.

We studied the effect of a new complex phytocomposition on age-related changes in the composition of biological fluids (blood, lymph, and interstitial fluid) in old (22-24-month-old) white Sprague-Dawley rats. A 3-month course of phytocomposition induced an increase in the volumes of interstitial fluid (IF) and plasma and stimulated lymph outflow and diuresis. In the blood and lymph, the clotting time increased, while the viscosity and all lipid indicators decreased.

The Specifics of Adrenergic Innervation of Lymph Nodes from Different Body Regions in Young, Mature, and Old Animals.

Adrenergic innervation in the tissue of the cervical, mesenteric, and popliteal lymph nodes in rats of different age groups (from 2-45 days to 24 months) was studied using the specific fluorescence-microscopic imaging of catecholamines. Adrenergic innervation in the lymph nodes of rats is present from the first days of life, but it develops and complicates during postnatal ontogeny and is fully formed by thedays 20-30 of life. By the age of one month, adrenergic innervation represents a well-formed apparatus in all parts of the node, i.

Contractile Activity of Lymph Nodes in Young, Middle-Aged, and Old Rats.

We studied age-associated changes in contractile activity of isolated cervical and mesenteric lymph nodes in rats. In young and middle-aged rats, no significant changes in contractile activity of lymph nodes were revealed. In old rats, the amplitude of spontaneous contractions of lymph nodes was lower and their rate was higher than in young and middle-aged animals; the sensitivity of lymph nodes to vasoactive agents was reduced and the threshold of the response was higher in old rats.