The effects of electrical stimulation of the paleocerebellar cortex on penicillin-induced convulsive activity in rats.

Studies in Wistar rats in conditions of free behavior showed that low-frequency stimulation of the paleocerebellar cortex (nodulus, uvula) (10-12 Hz, 0.5 msec) was accompanied by activation of spike discharges induced by systematic application of benzylpenicillin sodium (3,000,000 IU/kg). Facilitation of the formation of ictal discharges was also seen.

Dependence of biological response on the geometric and electronic characteristics of phenol derivatives with smoke flavour.

On the base of the data of conformational analysis and quantum-chemical calculation (method CNDO/2) of the series of phenol derivatives with smoke flavour it was shown that the structural fragment responsible for the odorant activity consists of the oxygen atom and two hydrogen atoms. The atomic orbitals of these atoms are constituting the highest occupied molecular orbital (HOMO) with the high values of the orbital coefficients of their 2p pi- and 1s-orbitals. The distance between the hydrogen atoms is 1.