[Reaction of the sympathoadrenal system in young children with congenital heart defects during cardiopulmonary bypass surgery].

Reactions of the sympathoadrenal system were studied during surgical interventions in children aged 1.5-3 years with congenital heart disease operated under conditions of artificial circulation and hypothermia. The state of the sympathoadrenal system was different in uneventful and complicated course of the operation, which may indicate a different efficiency of the neurovegetative blocking and antistress protection from surgical trauma.

[The central hemodynamic changes and reaction of the sympathoadrenal system with the use of an original Russian analgesic fenaridin as the analgetic component of general anesthesia during aortocoronary bypass operations in patients with chronic ischemic heart disease].

The effect of fenaridine on the central hemodynamics and sympathoadrenal system was studied in 12 chronic coronary patients subjected to aortocoronary shunting and administered this drug as an analgetic component of general anesthesia. A reduction of heart rate, systolic arterial pressure, pressure in the pulmonary artery, total pulmonary resistance, more expressed decrease of cardiac index and stroke index, and an increase of total peripheral vascular resistance were observed. Analysis of the results permitted us to propose vasodilating effect of the drug, leading to a moderate reduction of cardiac index, and followed by a compensatory increase of vascular resistance, as the basic mechanism of these changes.