Publications by authors named "B A Kraemer"
Article Synopsis
- Deep endometriosis (DE) is a severe form of endometriosis affecting deeper tissue layers and can cause various symptoms, including severe pain and organ dysfunction.
- The article discusses the challenges in diagnosing and surgically treating DE at a Level III Endometriosis Center in Germany, highlighting the complexity of procedures and high rates of interdisciplinary collaboration.
- Despite the intricate nature of the surgeries, severe postoperative complications are rare, occurring in only 3.1% of cases, emphasizing the importance of specialized treatment at advanced centers.
Article Synopsis
- Alzheimer's disease is linked to the misfolding of beta-amyloid and tau proteins, leading to cellular toxicity.
- Activation of the heat shock response (HSR) pathway helps protect against the toxic effects of both beta-amyloid and tau proteins, improving cell function and longevity.
- Small molecules like Geranylgeranylacetone (GGA) and Arimoclomol (AC) can enhance the HSR, providing potential therapeutic strategies for treating Alzheimer's-related tauopathies.
The p75 Neurotrophin Receptor (p75 ) is a multifunctional transmembrane protein that mediates neuronal responses to pathological conditions in specific regions of the nervous system. In many biological contexts, p75 signaling is initiated through sequential cleavage of the receptor by α- and γ-secretases, which releases receptor fragments for downstream signaling. Our previous work demonstrated that proteolytic processing of p75 in this manner is stimulated by oxidative stress in Lund Human Mesencephalic (LUHMES) cells, a dopaminergic neuronal cell line derived from human mesencephalic tissue.
View Article and Find Full Text PDFEndometriosis is known to be a common chronic disease that often affects the quality of life of patients. Especially for deep endometriosis (DE), the most challenging form of the disease, surgery remains an important component of treatment. However, long-term outcomes after surgery are poorly studied.
View Article and Find Full Text PDFIntroduction: The curriculum for a da Vinci surgeon in gynecology requires special training before a surgeon performs their first independent case, but standardized, objective assessments of a trainee's workflow or skills learned during clinical cases are lacking. This pilot study presents a methodology to evaluate intraoperative surgeon behavior in hysterectomy cases through standardized surgical step segmentation paired with objective performance indicators (OPIs) calculated directly from robotic data streams. This method can provide individual case analysis in a truly objective capacity.
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