Publications by authors named "B A Kohler"
Childhood cancers are a heterogeneous group of rare diseases, accounting for less than 2% of all cancers diagnosed worldwide. Most countries, therefore, do not have enough cases to provide robust information on epidemiology, treatment, and late effects, especially for rarer types of cancer. Thus, only through a concerted effort to share data internationally will we be able to answer research questions that could not otherwise be answered.
View Article and Find Full Text PDFWe present the results from kinetic theory for a system of self-propelled particles with alignment interactions of higher-order symmetry, particularly nematic ones. To this end, we use the Landau equation approach, a systematic approximation to the BBGKY hierarchy for small effective couplings. Our calculations are presented in a pedagogical way with the explicit goal of serving as a tutorial from a physicists' perspective into applying kinetic theory ideas beyond mean-field to active matter systems with essentially no prerequisites and yield predictions without free parameters that are in quantitative agreement with direct agent-based simulations.
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- MGMT silencing occurs in about 6-7% of pancreatic cancer (PAC) cases and is more common in tumors with non-ductal histology and KRAS wild type status.
- This silencing is linked to longer overall survival and is associated with fewer KRAS mutations, as well as immune exclusion features.
- The study suggests that MGMT-silenced PACs may respond better to treatments involving alkylating and DNA damaging agents, pointing to the potential for targeted therapy combinations.
Background: Drinking water at US Marine Corps Base Camp Lejeune, North Carolina, was contaminated with trichloroethylene and other industrial solvents from 1953 to 1985.
Methods: A cohort cancer incidence study was conducted of Marines/Navy personnel who began service and were stationed at Camp Lejeune () or Camp Pendleton, California () between 1975 and 1985 and civilian workers employed at Camp Lejeune () or Camp Pendleton () between October 1972 and December 1985. Camp Pendleton's drinking water was not contaminated with industrial solvents.