[Aging, age-related diseases, and certain risk factors of cardiovascular diseases in subjects of advanced and senile age].

The aim of the work was to study sex-specific differences between certain risk factors of cardiovascular diseases and hemodynamic parameters in elderly subjects and their relation to age-specific diseases and genealogic history of longevity. Total cholesterol, triglyceride, glucose, fibrinogen, uric acid, urea, creatinine levels in plasma and arterial pressure (AP) were measured. Hemodynamic parameters were calculated by the formulas for the stroke volume, cardiac output, myocardial contractility, pulse pressure, total peripheral resistance (TPR), endurance factor of cardiac activity, and Kerdo index.

[Longevity: 1. Social, clinical and some metabolic aspects].

We haven't found or identified individual risk factors of cardiovascular diseases (smoking, drinking habit) and a later accession of other risk factors (arterial hypertension, left ventricular hypertrophy, anemia, hyperfibrinogenemia) in nonagenarians with different age-related diseases. This age group was characterized by comorbidity, delayed onset of the disease with fewer complications and some features of metabolism as compared to other age groups. These results enable us to consider longevity as possible model of successful aging.

[Comparative study of the features of protein composition of human aorta tunica media].

A preliminary two-dimensional map of human aorta tunica media proteins comprising 280 polypeptide fractions has been constructed. Individual protein fractions were characterized in terms of molecular masses and relative electrophoretic mobility; the resulting values were stored in the "protein" data base. Using co-electrophoresis, the positions of certain tunica media proteins (light chains, myosin, tropomyosin, actin, albumin) was determined.

Proteins of human chorionic villi tissue: construction of a protein map based upon fractionation by two-dimensional gel electrophoresis.

Proteins of human chorionic villi from the first trimester of pregnancy were studied by high-resolution two-dimensional gel electrophoresis. One hundred and ninety-eight proteins spots were identifiable and allowed the plotting of a two-dimensional map of the proteins of human chorionic villi from the eighth week of pregnancy. The proteins of human chorionic villi from the twelfth week of gestation and of villi from term placenta were also studied.

[Clinical polymorphism in amenorrhea of chromosomal and nonchromosomal etiologies].

In search of the basis of distinguishing amenorrhea, due to chromosomal mosaicism and other causes, 179 females affected by primary or secondary amenorrhea were examined, 83 of them being 45,X/46,XX mosaics. 119 traits characterizing the morphological status of the musculoskeletal and reproductive systems, as well as skin, hair and nails were scored. By means of statistical approaches, a group of 21 traits were specified, which makes it possible to diagnose the amenorrhea of chromosomal origin.