Publications by authors named "B A Hunter"
Background: Sepsis is a leading cause of hospital mortality and there is evidence that outcomes vary by patient demographics including race and gender. Our objectives were to determine whether the introduction of a standardized sepsis order set was associated with (1) changes in overall mortality or early antibiotic administration or (2) changes in outcome disparities based on race or gender.
Methods: Patients seen in the emergency department and admitted to the hospital with a diagnosis code of sepsis were identified and divided into a preintervention cohort seen during the 18 months prior to the initiation of a new sepsis order set and an intervention cohort seen during the 18 months after a quality initiative driven by introducing the order set.
Article Synopsis
- * A study was conducted using mass spectrometry to analyze the differences in metabolome (metabolism) and proteome (proteins) between healthy left and right ventricles, revealing significant metabolic changes.
- * In advanced heart conditions like dilated and ischemic cardiomyopathy, the distinct metabolic pathways between the ventricles become less pronounced, but the left ventricle shows more adverse changes related to heart failure.
Background: The training characteristics and training intensity distribution (TID) of elite athletes have been extensively studied, but a comprehensive analysis of the TID across runners from different performance levels is lacking.
Methods: Training sessions from the 16 weeks preceding 151,813 marathons completed by 119,452 runners were analysed. The TID was quantified using a three-zone approach (Z1, Z2 and Z3), where critical speed defined the boundary between Z2 and Z3, and the transition between Z1 and Z2 was assumed to occur at 82.
High-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction.
J Heart Lung Transplant
November 2024
Article Synopsis
- The study investigates the immune mechanisms behind chronic lung allograft dysfunction (CLAD), which hampers long-term survival after lung transplants, using advanced tissue imaging techniques.
- Researchers analyzed lung tissue from 23 transplant recipients, identifying differences in immune cell populations associated with CLAD versus non-CLAD conditions.
- Key findings show that specific immune cells, like cytotoxic T cells and γδ T cells, expand in CLAD, highlighting unique characteristics in different CLAD phenotypes and offering new insights into how fibrosis progresses in these conditions.*
Unlabelled: Diagnosing cancer in general practice is complex, given the non-specific nature of many presenting symptoms and the overlap of potential diagnoses. This trial evaluated the effectiveness of a technology, Future Health Today (FHT), which provides clinical decision support, auditing, and quality improvement monitoring, on the appropriate follow-up of patients at risk of undiagnosed cancer.
Methods: Pragmatic, cluster randomised trial in Australian general practice.