An 8-year Experience of Robot-Assisted Laparoscopic Surgical Management of Median Arcuate Ligament Syndrome.

Background: Due to the rarity of median arcuate ligament syndrome (MALS), surgical approaches to median arcuate ligament release (MALR) have been understudied. This series aimed to review robot-assisted laparoscopic MALR from a quaternary care center.

Methods: This is a single center cohort study of adult patients who underwent robot-assisted laparoscopic MALR between March 2015 and June 2023.

Retrospective Perceptions of Life Satisfaction Change: Evaluation Strategies and Correspondence With Measured Change.

Life satisfaction has been shown to change over time, but we know little about how people perceive those changes. In preregistered analyses, the current research investigated the degree of correspondence between people's retrospective perceptions of life satisfaction change and their measured life satisfaction change (Sample A analytic = 359; Sample B analytic = 336). On average, retrospective perceptions of change were moderately correlated with measured change ( = .

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Expanded CAG alleles in the huntingtin () gene that cause the neurodegenerative disorder Huntington's disease (HD) are genetically unstable and continue to expand somatically throughout life, driving HD onset and progression. MSH3, a DNA mismatch repair protein, modifies HD onset and progression by driving this somatic CAG repeat expansion process. is relatively tolerant of loss-of-function variation in humans, making it a potential therapeutic target.

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy.

Cellular therapies are living drugs whose efficacy depends on persistence and survival. Expansion of therapeutic T cells employs hypermetabolic culture conditions to promote T cell expansion. We show that typical in vitro expansion conditions generate metabolically and functionally impaired T cells more reliant on aerobic glycolysis than those expanding in vivo.

Helping authors produce FAIR taxonomic data: evaluation of an author-driven phenotype data production prototype.

It is well-known that the use of vocabulary in phenotype treatments is often inconsistent. An earlier survey of biologists who create or use phenotypic characters revealed that this lack of standardization leads to ambiguities, frustrating both the consumers and producers of phenotypic data. Such ambiguities are challenging for biologists, and more so for Artificial Intelligence, to resolve.