Publications by authors named "B A Domin"
Article Synopsis
- * Significant findings include higher neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) in SOCV patients compared to healthy controls, along with specific predictors of disease severity and hospitalization length.
- * Key results show that upper extremity manifestations suggest milder disease, while older age and lower serum C3 levels predict longer hospital stays and higher recurrence rates, highlighting the importance of these factors in patient prognosis.
Article Synopsis
- The study focuses on two types of immune complex vasculitides in adults: IgA small vessel vasculitis (aIgA-SVV) and non-IgA small vessel vasculitis (non-IgA-SVV).
- Researchers analyzed clinical and laboratory data from 29 patients with aIgA-SVV and 53 with non-IgA-SVV to identify differences in their conditions.
- Key findings revealed that patients with aIgA-SVV showed higher rates of proteinuria and haematuria, while non-IgA-SVV patients had a higher platelet-to-lymphocyte ratio, indicating notable clinical distinctions between the two groups.
Abacavir, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol, is a novel purine carbocyclic nucleoside analogue that has been approved by the FDA for the treatment of HIV (as Ziagen trade mark [abacavir sulfate]). Chemically, abacavir and (-)-carbovir (CBV) differ only at the 6-position of the purine ring; abacavir contains a cyclopropylamino moiety in place of the 6-lactam functionality of CBV. Intracellularly both are ultimately metabolized to CBV triphosphate.
View Article and Find Full Text PDFLoss of adipose tissue in cancer cachexia has been associated with tumour production of a lipid-mobilizing factor (LMF) which has been shown to be homologous with the plasma protein zinc-alpha(2)-glycoprotein (ZAG). The aim of this study was to compare the ability of human ZAG with LMF to stimulate lipolysis in vitro and induce loss of body fat in vivo, and to determine the mechanisms involved. ZAG was purified from human plasma using a combination of Q Sepharose and Superdex 75 chromatography, and was shown to stimulate glycerol release from isolated murine epididymal adipocytes in a dose-dependent manner.
View Article and Find Full Text PDFThe high affinity L-proline transporter (PROT) is a member of the family of Na+ (and Cl-)-dependent plasma membrane transport proteins that comprises transporters for several neurotransmitters, osmolytes, and metabolites. The brain-specific expression of PROT in a subset of putative glutamatergic pathways implies a specialized function for this novel transporter and its presumed natural substrate L-proline in excitatory synaptic transmission. However, definitive studies of the physiological role(s) of high affinity L-proline uptake have been precluded by the lack of specific uptake inhibitors.
View Article and Find Full Text PDF