Publications by authors named "B A Deepika"
Background: Cancer is the deadliest disease, and neurological disorders are also marked as slow progressive diseases, ultimately leading to death. Stopping two mouths with one morsel was the strategy that we used in this study.
Methods: We have synthesized peony-shaped zinc oxide nanoflowers (ZnO-NFs) and characterized them using various photophysical tools like UV-vis spectroscopy, zeta potential analysis, dynamic light scattering (DLS), FTIR, and scanning electron microscopy (SEM), and utilized these nanoflowers to monitor their anticancer and anti-amyloid activity.
Wound healing is a complex process that can be improved through advanced biomedical approaches. Incorporating nanopolymers and plant extracts into wound dressings offers a favorable strategy for promoting tissue repair. Nanopolymers provide a controlled environment for sustained drug release while also protecting the wound from external contaminants.
View Article and Find Full Text PDFAmyloids, with their β-sheet-rich structure, contribute to diabetes, neurodegenerative diseases, and amyloidosis by aggregating within diverse anatomical compartments. Insulin amyloid (IA), sharing structural resemblances with amyloids linked to neurological disorders, acts as a prototype, while compounds capable of degrading these fibrils hold promise as therapeutic agents for amyloidosis intervention. In this research, liposomal nanoformulated iota carrageenan (nCG) was formulated to disrupt insulin amyloids, demonstrating about a 17-20 % higher degradation efficacy compared to conventional carrageenan through thioflavin T fluorescence, dynamic light scattering analysis, and turbidity quantification.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the toxic effects of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in both lab models, specifically zebrafish embryos and Swiss albino mice, confirming their composition through phytochemical analysis.
- - In vitro tests showed that both EEP and N-EEP affected normal lung cells in a dose-dependent manner, while no developmental issues were seen in zebrafish embryos at a concentration of 200 µg/ml.
- - Acute and sub-acute toxicity tests in mice revealed that doses below 600 mg/kg of EEP and N-EEP can be considered safe for treating various diseases, as evidenced by observed physiological parameters and histopathological analyses
Objective: To investigate the potential role of a novel m6A RNA regulator, Insulin-like Growth Factor-2 mRNA-binding protein 1 (IGF2BP1), in periodontal disease pathogenesis.
Materials And Methods: Gingival tissue samples from 60 periodontitis patients and 60 healthy individuals were analyzed for IGF2BP1 mRNA and protein expression real-time quantitative PCR (RT-qPCR) and Western blotting. Additionally, Lipopolysaccharide (Pg-LPS) -induced human gingival fibroblasts (HGFs) were evaluated for IGF2BP1 and proinflammatory cytokine expression.