Publications by authors named "B A C Housmans"
Article Synopsis
- The study aimed to differentiate osteoarthritis (OA) patients by analyzing their serum-induced cellular signaling patterns, using samples from knee OA patients, hand OA patients, and healthy controls.
- Results showed significant differences in cellular pathway activity based on the type of OA, with hand OA serum triggering higher MAPK-related AP1 activity, while knee OA serum affected other pathways related to ELK1-SRF, STAT1-STAT2, and SOX9.
- The findings suggest that the underlying mechanisms of OA differ between hand and knee OA, potentially paving the way for more targeted treatments based on specific OA endotypes.
Alterations in cell fate are often attributed to (epigenetic) regulation of gene expression. An emerging paradigm focuses on specialized ribosomes within a cell. However, little evidence exists for the dynamic regulation of ribosome composition and function.
View Article and Find Full Text PDFEukaryotic ribosomes are complex molecular nanomachines translating genetic information from mRNAs into proteins. There is natural heterogeneity in ribosome composition. The pseudouridylation (ψ) of ribosomal RNAs (rRNAs) is one of the key sources of ribosome heterogeneity.
View Article and Find Full Text PDFObjective: Basic Calcium Phosphate (BCP) crystals play an active role in the progression of osteoarthritis (OA). However, the cellular consequences remain largely unknown. Therefore, we characterized for the first time the changes in the protein secretome of human OA articular chondrocytes as a result of BCP stimulation using two unbiased proteomic analysis methods.
View Article and Find Full Text PDFObjective: Osteoarthritis-related cartilage extracellular matrix remodeling is dependent on changes in chondrocyte protein expression. Yet, the role of ribosomes in chondrocyte translation regulation is unknown. In this exploratory study, we investigated ribosomal RNA (rRNA) epitranscriptomic-based ribosome heterogeneity in human articular chondrocytes and its relevance for osteoarthritis.
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