[Influence of some simple phenols on biochemical and morphological indices of rat blood].

Influence of various doses of xenobiotics on several biological and morphological indices of rat blood has been studied. It was established that intraperitoneal injections of the investigated phenols resulted in effect on biochemical indices of rat blood, specific to the particular phenolic compound. The strongest effect was observed in case of 4-nitrophenol and the weakest one was in case of hydroquinone; it witnesses for strong toxicity of 4-nitrophenol and for antioxidant properties of hydroquinone.

[Influence of different type beta-adrenoblockers on functional state of liver at paracetamol induced toxic hepatitis in experiment].

The aim of the present work was comparative analyze of different type beta-adrenoblockers (nonselective beta-AB-Propranolol; cardio selective beta1-AB-Bisoprolol; nonselective beta-AB with additional vasodilatory effects - carvedilol) on functional state of liver at Paracetamol induced toxic hepatitis in experiment. Experiments were carried out on 42 laboratory white rats with the body mass 180-200 g. Model of acute toxic hepatitis was created using paracetamol (peroral administration with the dose of 1000 mg/kg, once a day).

[Influence of phenol on biochemical and morphological indices of blood in rats].

Influence of different doses of phenol on some biological and morphological indices of rat blood was studied. It has been established that glucose and total protein concentration decreased, but beta-lipoprotein concentration increased in response to intraperitoneal injection of xenobiotic. The morphological study of structural indices of blood formed elements has demonstrated that intensively of the defensive response of blood formed elements was phenol dose-dependent.

[Influence of 4-nitrophenol on some biochemical and morphological indices of rat blood].

Influence of different doses of 4-nitrophenol on some biochemical and morphological indices of rat blood was studied. Glucose and beta-lipoprotein concentration increased, but total protein concentration decreased in response to intraperitoneal injection of xenobiotic. As a result of xenobiotic action, the total amount of leukocytes and thrombocytes increased, while the amount of erythrocytes decreased.

Detoxication mechanism of exogenous monatomic phenols in pea seedlings.

The conversion of exogenous monatomic phenols (O-[1-(14)C]nitrophenol, 2,4-[1-14C]dinitrophenol, and alpha-[1-14C]naphthol) in pea seedlings has been investigated. It has been found that in the pea seedlings glycosylation of these phenols does not occur, but the main pathway of their detoxication is conjugation with the low-molecular-weight peptides. Approximately 80% of phenols absorbed by seedlings form phenol-peptide conjugates.