Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial.

Background: Monotherapy with the drug isoniazid (INH) was for a long time the main therapeutic regimen used for tuberculosis preventive treatment (TPT). Research is progressing into the use of new therapeutic regimens that provide more complete TPT. The objective was to analyze the completion and safety of TPT with the drug INH in the form of 300 mg tablets.

Leukemia inhibitory factor in peripheral blood as a prognostic marker in breast cancer.

Purpose: Analysis of gene expression profiles in peripheral blood cells has been explored as an approach for early detection of breast cancer. Thus, we aimed to evaluate the diagnostic and prognostic potential of LIF expression in the peripheral blood of women with breast cancer.

Methods: A total of 121 women over 18 years of age with breast cancer and 80 healthy women were included.

Prolonged post-weaning protein restriction induces gut dysbiosis and colonic dysfunction in male mice.

Insufficient or imbalanced protein can disrupt gut microbiota, potentially compromising gut barrier function and increasing health risks. Herein, we investigated the effects of protein restriction on cecal microbiota and colon morphofunction in male mice. From 30 to 120 days of age, mice were fed a control protein diet [14% protein, control (C) group] or a low-protein diet [6% protein, protein-restricted (R) group].

Pigment Production by sp.: Extract Production, Cytotoxicity Activity, and Diketopiperazines Identified.

Filamentous fungi are among the most commonly used microorganisms for producing various metabolites including dyes. Ensuring the safety of products derived from microorganisms is always essential. In this study, the isolated fungus was identified as sp.

Application of Z-scan technique in detecting circulating free DNA for prostate cancer diagnosis and monitoring.

Prostate cancer diagnosis relies on methods like PSA testing, digital rectal exams, and biopsies. The Z-scan technique, a nonlinear optical method, may provide a new, non-invasive approach to detecting circulating free DNA (ccfDNA) in serum, offering potential improvements in cancer diagnosis and monitoring. The aim of this study is to evaluate whether the Z-scan technique can serve as an alternative or complementary diagnostic tool to existing prostate cancer tests.