Comparison of the therapeutic effectiveness of human CD34 and rat bone marrow mesenchymal stem cells on improvement of experimental liver fibrosis in Wistar rats.

Background And Objective: Human umbilical cord blood (UCB) cells and bone marrow mesenchymal stem cells (BM-MSCs) have numerous advantages as grafts for cell transplantation. We hypothesized differing impacts of human UCB cells and rat BM-MSCs on reversal of hepatic injury and revival of liver function in carbon tetrachloride (CCl)-induced liver fibrosis.

Methods: Forty rats were divided into 4 groups; control group, CCl group, CCl/CD34 group and CCl/BM-MSCs group.