Prognostic factors and outcome of relapsed/progressive pediatric Ewing sarcoma: single-center 10-year experience.

Background: Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children and adolescents. Despite more intensive chemotherapy regimens and improved local control therapy, there is still a considerable rate of recurrent/progressive disease.

Methods: A retrospective study of 50 relapsed/progressive ES patients who were treated at the National Cancer Institute (NCI), Cairo University, during the period from 1st of January 2008 to the end of December 2018, to assess different prognostic variables and disease outcomes.

Nephrectomy for Pediatric Renal Tumors: A Modified Surgical Approach to Minimize Post-operative Intestinal Obstruction.

Background: The authors present a modified surgical technique during tumor nephrectomy in children with a conservative approach towards small bowel manipulation and cutting of the peritoneal reflections. We aimed to evaluate this modified surgical approach regarding the incidence of post-operative small bowel obstruction (SBO), and its technical utility.

Methods: The study includes all children with unilateral renal tumors who underwent radical nephrectomy and lymph nodes sampling at our tertiary center from 2010 to 2022.

Stage I seminoma: Outcome of different treatment modalities and changes in patterns of care. A single institution experience.

Background: The mainstay for management of stage I seminoma is high inguinal orchiectomy with post-orchiectomy therapeutic options including active surveillance, chemotherapy or radiation therapy.

Objectives: To analyze different post-orchiectomy treatment modalities outcomes of stage I seminoma patients presented to NCI, Cairo University in the period from 2005-2019.

Patients And Methods: A retrospective review of all patients' records with clinical stage I seminoma who presented to our institute in the period from 2005-2019 was done.

Hypofractionated Radiation Therapy For Diffuse Intrinsic Pontine Glioma: A Noninferiority Randomized Study Including 253 Children.

Purpose: Pediatric diffuse intrinsic pontine glioma is an orphen disease. This study aimed to confirm the noninferiority of hypofractionated (HF) radiation therapy. Identification of the prognostic factors that determine the overall survival (OS) and progression-free survival (PFS) was the secondary objective.

The first BGICC consensus and recommendations for breast cancer awareness, early detection and risk reduction in low- and middle-income countries and the MENA region.

In low-middle income countries (LMICs) and the Middle East and North Africa (MENA) region, there is an unmet need to establish and improve breast cancer (BC) awareness, early diagnosis and risk reduction programs. During the 12th Breast, Gynecological & Immuno-oncology International Cancer Conference - Egypt 2020, 26 experts from 7 countries worldwide voted to establish the first consensus for BC awareness, early detection and risk reduction in LMICs/MENA region. The panel advised that there is an extreme necessity for a well-developed BC data registries and prospective clinical studies that address alternative modalities/modified BC screening programs in areas of limited resources.

Whole lung irradiation for completely responding pulmonary metastases in pediatric Ewing sarcoma.

Scarce data assessing the real value of whole lung irradiation (WLI) in Ewing's sarcoma (ES) with lung-only metastasis, with published conflicting results. We studied the impact of WLI in a homogenous pediatric population. Retrospective study evaluating the survival outcomes of WLI in these patients.

Outcome of cervix uteri cancer patients: Clinical treatment results and toxicity profile in a retrospective study from Saudi Arabia.

Aim: This study evaluated the survival outcome, pattern of failure and prognostic factors in cervix uteri cancer patients.

Methods: We reviewed the data of 60 patients with stages IB-IVA cancer who were treated between January 2004 and December 2010.

Results: Most patients (n = 50; 83%) had squamous cell carcinoma.

Dosimetric prospective study comparing 2D and 3D planning for irradiation of supraclavicular and infraclavicular regions in breast cancer patients.

Purpose: The purpose of this study is to compare 2D plan and 3D plan regarding coverage of the target (supraclavicular and infraclavicular regions) and dose reaching the risk organs (using mean DVH). Depending on the results of this study, modifications can be made to the 2D conventional planning of supraclavicular and infraclavicular regions in order to achieve better coverage of the target tissues.

Materials And Methods: This is a dosimetric study carried out at the radiation oncology department in NCI-Cairo University in the period from January 2012 to October 2012, on 15 patients with breast cancer who are eligible for supraclavicular and infraclavicular irradiation.

Dosimetric analytic comparison of inverse and forward planned IMRT techniques in the treatment of head and neck cancer.

Purpose: Our aim was to investigate if, and to what degree, improvements of IMRT treatment plans generated by forward planning can be achieved with an inverse planning strategy for treatments of head and neck cancer.

Methods: Between June 2007 and April 2008, 19 patients with head-and-neck cancers were treated at KAAH and Oncology Center Jeddah, using forward planning intensity modulated radiation therapy (FP-IMRT). They received thirty fractions over six weeks, to simultaneously deliver 66 Gy to the gross tumor (CTV1), 60 Gy to the soft tissue and nodes adjacent to the previous volume (CTV2), and 54 Gy to elective nodes (CTV3).

Locally advanced rectal carcinoma: preoperative radiotherapy versus postoperative chemoradiation, 10-year follow-up results of a randomized clinical study.

Purpose: A prospective study was designed to randomize locally advanced rectal carcinoma patients between either preoperative radiotherapy (+/- postoperative chemotherapy) or postoperative adjuvant chemoradiation. Two end points were evaluated, local recurrence and survival, aiming at defining prognostic parameters that can help in the choice of the optimum treatment modality.

Patients And Methods: This is a prospective randomized clinical study including patients with locally advanced low rectal cancer treated at the National Cancer Institute (NCI), Cairo University, during the period from December 1994 to January 1999.

The prognostic impact of additional chemotherapy to radiation therapy for postoperative management of pediatric medulloblastoma.

Purpose: The aim of this study is to evaluate treatment results of combined therapy; surgery, postoperative craniospinal radiotherapy with chemotherapy compared to treatment with postoperative radiotherapy only. Also to assess the effect of extent of surgical resection on prognosis.

Patients And Methods: Between 1993 and 2003, 34 children > 3 years of age with nondisseminated medulloblastoma were treated with postoperative, craniospinal radiation therapy (36 Gy in 20 fractions to the craniospinal axis, supplemented by a posterior fossa dose of 1980 cGy in 11 fractions (total dose of 56 Gy).