Protective effect of magnetic water against AlCl-induced hepatotoxicity in rats.

This study aimed to examine whether or not aluminum chloride (AlCl)-induced hepatotoxicity might be mitigated using magnetic water (MW) in rats. This study involved 28 adult male rats randomly assigned into the following 4 groups (7 rats/group): normal control (Cnt), MW, AlCl, and Al Cl + MW. The Cnt group orally received normal saline, the MW group drank MW ad libitum for 2 months, and the AlCl and AlCl + MW groups were orally administered AlCl (40 mg/kg b.

Lyophilized growth factor intralesional injection in female pattern hair loss: A clinical and trichoscopic study.

Various therapeutic modalities have been tried for female pattern hair loss (FPHL) treatment. To our knowledge, no previous studies had evaluated the therapeutic effect of lyophilized growth factor (L-GF) intralesional injection in FPHL. The current study aimed to evaluate the efficacy and safety of intralesional L-GF injection in FPHL by clinical and trichoscopic evaluation.

Intense pulsed light versus cryotherapy in the treatment of hypertrophic scars: A clinical and histopathological study.

Background: Different therapeutic modalities have been tried for hypertrophic scar treatment. To our knowledge, intense pulsed light (IPL) has not been previously evaluated in comparison with cryotherapy as a stand-alone treatment for hypertrophic scars.

Objective: We aimed to evaluate the efficacy of IPL as a monotherapy for hypertrophic scar treatment as compared with cryotherapy both clinically and histopathologically.

Ablative fractional CO laser vs lyophilized growth factor intralesional injection vs combination of both modalities for striae distensae treatment.

Background: Different studies had evaluated the efficacy of fractional CO laser and platelet-rich plasma (PRP) in treating striae distensae (SD). Lyophilized growth factors (LGF) represent another form of delivering growth factors similar to PRP with a more standardized method. To the best of our knowledge, no previous trials have been reported using LGF in SD.

The dermoscopic features of facial aging among Egyptians: A comparative study between males and females.

Background: Few studies have evaluated facial photoaging by dermoscopy. Only one study has been performed among Egyptians.

Objective: To study and compare the dermoscopic features of facial aging in males and females and to relate these features to clinical criteria.

Miniaturized membrane sensors for potentiometric determination of metoprolol tartrate and hydrochlorothiazide.

Four microsized graphite and platinum wire poly(vinyl chloride) matrix membrane electrodes responsive to some drugs affecting cardiovascular system, Metoprolol tartrate (MT) and Hydrochlorothiazide (HZ) were developed, described and characterized. These sensors were constructed by using (2-Hydroxypropyl)-β-cyclodextrin (2HP β-CD) as an ionophore which has a significant influence on increasing both membrane sensitivity and selectivity. The four sensors were fabricated in a polymeric matrix of carboxylated polyvinyl chloride (PVC-COOH) and dioctylphthalate (DOP) as a plasticizer, based on the interaction between the drugs and the dissociated COOH groups in the PVC-COOH.

Stability-indicating methods for the determination of mosapride citrate in the presence of its degradation products according to ICH guidelines.

In the present work, different spectrophotometric methods and one spectrofluorimetric method have been developed and validated for the determination of mosapride citrate in the presence of its acid-induced degradation products. The drug was subjected to stress stability study including acid, alkali, oxidative, photolytic, and thermal stress degradation. The developed spectrophotometric methods included the use of first order derivative ((1)D), derivative of ratio spectra ((1)DD), mean centring of ratio spectra (MC) and H-point standard additions (HPSAM) spectrophotometric methods.

Simultaneous determination of metformin hydrochloride and pioglitazone hydrochloride in binary mixture and in their ternary mixture with pioglitazone acid degradate using spectrophotometric and chemometric methods.

In this work two well known oral hypoglycemic drugs that are administered in combination for patients with type-II diabetes were simultaneously determined. Several spectrophotometric methods were developed and validated for the determination of metformin hydrochloride (MET), pioglitazone hydrochloride (PIO) and pioglitazone acid degradate (PIO Deg). Derivative, ratio derivative, isosbestic and chemometric-assisted spectrophotometric methods were developed.

Correction of aberrant pre-mRNA splicing by antisense oligonucleotides in beta-thalassemia Egyptian patients with IVSI-110 mutation.

The splicing mutation in intron 1 of beta-globin gene (IVS1-110) is the most common mutation in Egyptian thalassemics that causes aberrant splicing of pre-mRNA and deficient beta-globin chain synthesis. Antisense oligonucleotides (ASONs) are compounds that redirect pre-mRNA splicing and modify gene expression. Our aim was ex vivo correction of the aberrant splicing of beta-globin110 pre-mRNA by ASON against the 3' aberrant splice site.

Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience.

Patients with thalassemia major requiring regular blood transfusions accumulate iron that is toxic to the heart, liver, and endocrine systems. The following prospective, randomized trial was carried out to determine the effectiveness, in children and young adults, of combined deferiprone (DFP) and deferoxamine (DFO) in reducing transfusional iron overload compared to either drug alone and to assess the safety and tolerability of DFP. Sixty-six patients were randomized into three treatment arms: daily DFP combined with DFO twice weekly; daily DFP only; and DFO only 5 days/week.

Use of bioassay and microplate assay to detect and measure insecticide resistance in field populations of Culex pipiens from filariasis endemic areas of Egypt.

Insecticide and resistance bioassays and microplate assays were performed on Culex pipiens mosquitoes to determine the level and mechanisms of resistance. Culex pipiens larvae were collected from three filariasis-endemic areas of Egypt and reared to adults for subsequent production and testing of F1 generation larvae and adults. Bioassays were performed using World Health Organization (WHO) methods with the diagnostic doses of 6 organophosphate insecticides for larvae and 1 organochlorine (OC), 4 pyrethroid, 2 organophosphate, and 2 carbamate insecticides for adults.

Dipterous flies species and their densities in fourteen Egyptian Governorates.

The present study focused on dipterous flies, distribution and densities in 14 Egyptian Governorates. The abundance and distribution of flies was carried out in three phases. The first was in 1999 in 5 governorates, Qalyobia, Menoufia, Fayium, Behiera & Assuit included species of the families: Calliphoridae, Chloropidae, Drosophilidae, Milichiidae, Muscidae, Otitidae, Piophilidae, Sarcophagidae, Sepsidae, Sphaeroceridae and Syrphidae.

Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study.

No identifiable cause can be found in more than half of the cases of portal vein thrombosis (PVT). Our aim was to assess the prevalence of factor V Leiden mutation and other thrombophilic factors as risk factors in the development of PVT in the pediatric age group. From March 2001 to January 2002, 40 children with PVT were enrolled in the study, in addition to 20 age-matched and sex-matched controls.

Field studies on the susceptibility of housefly to certain insecticides in nine Egyptian governorates.

Standard WHO test methods were used to determine the susceptibility of field population of housefly to four organophosphorous and two pyrethroid insecticides. Field population flies collected from nine governorates, Giza, Faiyoum, Suez, Behaira, Menoufia, Sharkia, Kafr El-Sheikh, Assiut and Aswan. The results indicated that, all tested insecticides were very effective on flies collected, from Sharkia, Kafr El-Sheikh and Aswan, but there was an evidence of increased vigor tolerance among those collected from Kafr El-Sheikh for bioresmethrin and tolerance for diazinon in Aswan.

Mosquito species and their densities in some Egyptian governorates.

The present work studied the mosquito's identification, distribution and densities in fourteen Egyptian Governorates. The abundance and distribution of mosquito species monitored by three phases. The first was carried out in 1999 in five governorates, Qalyobia, Menoufia, Behaira, Fayium and Assuit.

Spectrophotometric determination of clobetasol propionate, halobetasol propionate, quinagolide hydrochloride, through charge transfer complexation.

Two spectrophotometric procedures are described for the determination of clobetasol propionate(I), halobetasol propionate(II) (corticosteroids) and quinagolide hydrochloride(III) (prolactin inhibitor). For corticosteroid drugs, the procedures are based on the formation of phenyl hydrazones of the corticosteroids which are subsequently subjected to charge transfer complexation reaction with either 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as pi-acceptor or with iodine as sigma-acceptor. Prolactin inhibitor was reacted directly with the previous reagents.