Publications by authors named "Azza Al Ismail"
Int Immunol
December 2017
Article Synopsis
- AID is crucial for class-switch recombination and somatic hypermutation of immunoglobulin genes, with mutations in the C-terminal region impacting its function while leaving DNA cleavage and SHM intact.
- C-terminal AID mutations, like JP41, suppress CSR and chromosomal translocations through a dominant negative effect that affects the recombination process but not the initial DNA cleavage.
- JP41 expression reduces interaction between WT AID and key cofactors, suggesting that the dominant negative effect may result from decreased availability of specific RNA-binding proteins necessary for CSR.
