Publications by authors named "Azusa Nishinosono"
Article Synopsis
- Prolonged high-fat feeding in rodent models leads to increased fatty acid uptake and lipotoxicity, stressing the mitochondria in heart and muscle tissues.
- The study investigated the role of acyl-CoA thioesterase (ACOT) in mitigating this lipotoxicity by analyzing its expression levels in rats on low vs. high-fat diets for 20 weeks.
- Results showed significant increases in ACOT isoforms in the heart and soleus muscle of high-fat diet rats, suggesting that ACOT plays a protective role against excessive fatty acid accumulation.
