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Publications by authors named "Azusa Kambe"

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Transient Methionine Deprivation Triggers Histone Modification and Potentiates Differentiation of Induced Pluripotent Stem Cells.
Hiroki Ozawa Azusa Kambe Kodai Hibi Satoshi Murakami Akira Oikawa

Stem Cells

March 2023

Human induced pluripotent stem cells (iPSCs) require high levels of methionine (Met). Met deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM), poising human iPSCs for differentiation and leading to the apoptosis of undifferentiated cells. Met deprivation triggers rapid metabolic changes, including SAM, followed by reversible epigenetic modifications.

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Synopsis of recent research by authors named "Azusa Kambe"

  • - Azusa Kambe's research focuses on the effects of methionine deprivation on induced pluripotent stem cells (iPSCs), highlighting its role in epigenetic modifications and cellular differentiation.
  • - The study published in "Stem Cells" demonstrates that transient methionine deprivation decreases intracellular S-adenosyl-methionine (SAM) levels, promoting apoptosis in undifferentiated iPSCs while predisposing them for differentiation.
  • - Findings indicate that methionine deprivation triggers significant metabolic changes and reversible histone modifications, suggesting potential avenues for enhancing differentiation protocols in stem cell research.

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