Publications by authors named "Azura Mohd Noor"
Rapid and highly accurate diagnostic tools are critically needed to diagnose Mycobacterium tuberculosis and rifampicin resistance in AFB smear-negative samples. In this study, we evaluated the diagnostic performance of Xpert MTB/RIF Ultra (Ultra) as a rapid test to diagnose tuberculosis in smear-negative cases in Malaysia. A retrospective study of 1960 smear-negative pulmonary and extrapulmonary samples obtained from patients was conducted.
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- Brucellosis, a common zoonotic disease, poses a significant health issue globally, particularly in Malaysia where human brucellosis studies and genetic analysis are scarce.
- The study analyzed 43 Brucella melitensis and 2 Brucella suis isolates over six years using multiple-locus variable-number tandem-repeat analysis (MLVA), revealing low genetic diversity with a predominance of genotypes linked to the East Mediterranean group.
- This research is the first of its kind in Malaysia, highlighting the importance of B. melitensis in local Brucella infections and providing a foundation for future studies on the disease's genetic diversity.
Molecular approaches have been investigated to overcome difficulties in identification and differentiation of Brucella spp. using conventional phenotypic methods. In this study, high-resolution melt (HRM) analysis was used for rapid identification and differentiation of members of Brucella genus.
View Article and Find Full Text PDFBrucellosis is a world-wide zoonotic disease with a major impact on the public health. Due to the high risk of laboratory acquired infection, limited laboratory investigations were performed on this organism, including detailed identification and susceptibility study. Brucella melitensis is the commonest aetiological agent for human brucellosis in this region.
View Article and Find Full Text PDFAcute melioidosis may present as localised or septicaemic infections and can be fatal if left untreated. Burkholderia pseudomallei resistant to antibiotics used for the treatment of melioidosis had been reported. The aim of this study was to determine the in vitro antibiotic susceptibility patterns of Burkholderia pseudomallei isolated in Malaysia to a panel of antibiotics used for the treatment of melioidosis and also to potential alternative antibiotics such as tigecycline, ampicillin/sulbactam, and piperacillin/tazobactam.
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