Publications by authors named "Azumi Kaneko"
Article Synopsis
- The study found that in mouse embryonic stem cells, the expression of importin α switches from subtype α2 to α1 during neural differentiation, significantly affecting cell fate.
- Importin α2 prevents the nuclear import of key transcription factors like Oct6 and Brn2, maintaining the stem cell properties by keeping these factors in the cytoplasm.
- If this regulation by importin α2 is not reduced during differentiation, it can lead to improper cell death, highlighting its crucial role in ensuring correct timing for transcription factor activity.
