Differences between young and aged rats in voiding frequency and detrusor muscle serotonergic contraction.

Introduction: The involvement of serotonin (5-HT) in increased lower urinary tract symptoms in aging is unclear. We sought to compare voiding function and 5-HT induced detrusor contraction between young and aged rats.

Methods: This study used young (2- to 3-month-old) and aged (26- to 30-month-old) male Fischer 344 rats.