Publications by authors named "Azuah L Gonzalez"
Chronic inflammation has emerged as a major underlying cause of many prevalent conditions in the Western world, including cardiovascular diseases. Although targeting inflammation has emerged as a promising avenue by which to treat cardiovascular disease, it is also associated with increased risk of infection. Though previously assumed to be passive, resolution has now been identified as an active process, mediated by unique immunoresolving mediators and mechanisms designed to terminate acute inflammation and promote tissue repair.
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- Yersinia pseudotuberculosis and Yersinia pestis require a type III secretion system (T3SS) to evade immune defenses and cause disease, but its expression needs careful regulation due to its link to growth arrest and immune recognition.
- The expression of T3SS in Y. pseudotuberculosis is low in anaerobic, iron-rich conditions typical of the intestines, but increases in aerobic or iron-poor conditions faced when they encounter immune cells.
- The transcription factor IscR regulates T3SS expression by responding to oxygen and iron levels, and its binding to the lcrF promoter is crucial for virulence; this regulatory mechanism is conserved in both Y. pseudotuberculosis and Y. pest