THE POSOLOGY AND TROUGH CONCENTRATIONS OF DIGOXIN IN ADULT AND ELDERLY PATIENTS.

Being a narrow therapeutic index drug, digoxin may cause harm if dosed without regular measurements of serum levels. Due to various limitations in its dosing, different challenges still exist in clinical practice. This study aimed to assess digoxin though concentrations after different regimens in adult and elderly patients, and to identify predictor variables for the ratio of given dose and digoxin trough level.

Serum nitric oxide concentrations in patients with multiple sclerosis and patients with epilepsy.

Nitric oxide (NO), a neurotransmitter and a free radical, has been purported to be involved in numerous neurological diseases. We investigated the serum nitric oxide concentration in 30 patients with multiple sclerosis (MS), in 30 patients with epilepsy and in 30 control subjects. The aim was also to determine whether a statistically significant difference in serum NO concentrations exists between the groups of interest.

[The effect of lisinopril and amlodipine treatment on left ventricular hypertrophy in hypertensive patients].

Unlabelled: The aim of the study is an echocardiographic assessment of the influence of a long-term lisinopril treatment in combination with amlodipine in patients with LV hypertrophy.

Patients And Methods: In a clinical prospective study that lasted for 12 months, there were 20 subjects included whose blood pressure was under control. Prior to and after 12 months, there was an assessment of treatment efficacy through determining the values of blood pressure, cardiac frequency and echocardiographic examination of the heart, while the safety of administration was assessed based on the laboratorial blood and urine analysis and monitoring of undesirable effects.

Clinical study on safety and efficacy of the administration of amlodipine in a combination with lisinopril in hypertensive patients.

Aim: Evaluation of efficacy and safety of long-term (24 weeks) administration of a combined therapy of ACE inhibitors (lisinopril) and calcium-channel antagonists with long-term action (amlodipine) (with or without diuretics).

Method: A total number of 98 patients of both genders were included in the prospective, open trial. Evaluation of efficacy of the trial was carried out by careful monitoring of anamnesis and physical examination, blood-pressure values, pulse, body weight, ECG test and echocardiographic test.