Publications by authors named "Azmi Ahmat"

Objectives: Olanzapine has been shown to be effective in preventing chemotherapy-induced nausea and vomiting (CINV) after highly emetogenic chemotherapy (HEC); however, there is limited work on the impact of CINV on health-related quality of life (HRQoL) and the comparative cost-effectiveness of CINV prophylaxis in the Malaysian context. Therefore, this study was conducted to determine the HRQoL using EQ-5D-5L and the cost-effectiveness of olanzapine compared with aprepitant for CINV prophylaxis in Malaysia using data from a local study.

Methods: Fifty-nine chemo-naive patients receiving either olanzapine or aprepitant were randomly recruited and completed the EQ-5D-5L before and day 5 after HEC.

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Objectives: Early access to innovative oncology medicine is crucial to provide better treatment alternatives to patients with cancer. However, innovative oncology medicines often come at higher prices, thus limiting the government's ability for its universal coverage. Hence an alternative paying mechanism is needed.

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Objective: Cancer-associated venous thromboembolism (CAT) is a common disease or complication which is associated with reduced survival and incurring a substantial health-care cost. Low molecular weight heparin (LMWH) remained the gold standard treatment option available. Direct oral anticoagulants (DOACs) have recently become more popular in the guidelines, they are still few and inconsistent across the current literature.

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Article Synopsis
  • The study examines the effectiveness of vancomycin in treating methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in critically ill patients, highlighting the role of pharmacokinetic measures in treatment outcomes.
  • Out of 28 patients, 46% responded positively to vancomycin; however, non-responders had higher vancomycin minimum inhibitory concentration (MIC) levels and lower ratios of vancomycin concentration to MIC.
  • The study concludes that ratios of vancomycin trough concentration/MIC and area under the curve (AUC)/MIC are more reliable indicators of treatment success compared to trough concentration or AUC alone.
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