Turnaround Time of the Hematology Results of Cancer Patients During the COVID-19 Pandemic: An Opportunity to Initiate a Quality Improvement Process.

Introduction: Turnaround time (TAT) is a crucial clinical parameter that reflects the performance of a laboratory especially in the context of oncology and the COVID-19 pandemic. Based on the Lean Six Sigma methodology, we performed a retrospective analysis of the TAT of the complete blood count (CBC) of cancer patients with the aim of reducing this delay in the future.

Materials And Methods: Over one month of the COVID-19 pandemic, a retrospective evaluative audit was carried out on the TAT of the CBC in an oncology department.

Synthesis, structural characterizations, in vitro biological evaluation and computational investigations of pyrazole derivatives as potential antidiabetic and antioxidant agents.

In this study, a two pyrazole derivatives; 2-(5-methyl-1H-pyrazole-3-carbonyl)-N-phenylhydrazine-1-carboxamide (Pyz-1) and 4-amino-5-(5-methyl-1H-pyrazol-3-yl)-4H-1,2,4-triazole-3-thiol (Pyz-2) were synthesized and characterized by C-NMR, H-NMR, FT-IR, and mass spectrometry. A complete molecular structures optimization, electronic and thermodynamic properties of Pyz-1 and Pyz-2 in gas phase and aqueous solution were predicted by using hybrid B3LYP method with the 6-311++G** basis sets. Pyz-1 and Pyz-2 were evaluated in vitro for their anti-diabetic, antioxidant and xanthine oxidase inhibition activities.

Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis.

Chronic myeloid leukemia (CML) with BCR-ABL1-positive cells is a myeloproliferative neoplasm (MPN) characterized by a chromosomal translocation t(9,22)(q34.1;q11.2), which results in the formation of a Philadelphia (Ph) chromosome containing the BCR-ABL1 fusion gene.

Synthesis, design, , and (streptozotocin-induced diabetes in mice) biological evaluation of novels -arylacetamide derivatives.

The organic compounds 2-chloro--(aryl)acetamide and 2-azido--(aryl)acetamide were synthesized and analyzed using H, C NMR. The acute oral toxicity study was carried out according to OECD guidelines, which approve that the compounds (Ps18 and 153) were nontoxic. In addition, the compounds were evaluated for its antidiabetic and antihyperglycemic properties ( and ) and for antioxidant activity by utilizing several tests as 1,1-diphenyl2-picrylhydrazyl , (2,2'-azino-bis(3-ethyl benzthiazoline-6-sulfonicacid) , reducing power test and hydrogen peroxide activity .

Prevalence of anemia and associated factors in a Moroccan population from the Northwestern region of Morocco (M'diq-Fnideq-Martil Prefecture).

Introduction: anemia remains a major public health challenge worldwide, frequently having multifactorial causes and wide-ranging, largely underestimated repercussions. The purpose of this paper is to assess the prevalence of anemia and identify associated factors in a group of children, adults, and pregnant women.

Methods: our sample consisted of a total of 1360 volunteers (group I: 410 school-aged children aged 5-11 years; group II: 533 adults aged 16 to 65 years; group III: 417 pregnant women aged 17 to 45 years) randomly selected from different towns of the M'diq-Fnideq prefecture, Morocco from March 2018 to September 2018.

Determining Hematological Reference Intervals of the Blood Count in a Healthy Moroccan Adult Population (Al Hoceima Province).

Background: The hemogram is the most frequently prescribed laboratory test. It guides the complementary tests essential to the diagnosis and follow-up of the patient. Hematology reference values can be influenced by several parameters such as environmental and genetic factors, rendering it essential to define reference intervals (RIs) for specific populations.

Reference Intervals for Routine Biochemical Markers and Hematological Indices Derived from Healthy Adults in the Mediterranean Region of Morocco.

Background: Reference intervals (RIs) for biochemical and hematological parameters are fundamental tools for clinical diagnosis, management, and therapeutic follow-up. In Morocco, the RIs used by clinical laboratories and physicians are derived from western populations. Also, RIs of biochemical and hematological parameters specific to the various Moroccan areas are lacking.

Acute and Subacute Toxicity Studies of Extracts by Oral Administration in Rodents.

The present study aimed to evaluate the acute and subacute toxicity profiles of extracts in mice using the methods described in the guidelines of the OECD. In the acute toxicity study, the LD value was greater than 2000 mg/kg. The subacute toxicity study of extracts showed no significant changes in body or organ weights.

Blood donor eligibility after COVID-19 vaccination: the current state of recommendations.

The medical screening practices for blood donor eligibility after vaccination against several conventional infectious agents are well known to blood transfusion centres worldwide. Classically, blood donations are contraindicated for four weeks after vaccination with a live attenuated virus vaccine. For other types of vaccines, no postponement is necessary as there is no proven infectious risk.

[Combined deficiency of clotting factor V and factor VIII: about three siblings].

Combined deficiency of clotting factor V and factor VIII (DF5F8) is a congenital autosomal recessive disorder. This study involved a family of four children born to consanguineous parents. The eldest daughter was referred for assessment of activated partial thromboplastin time and prothrombin time associated with hemorrhagic manifestations.

Investigation of wound healing activity Cynara humilis of root extracts.

Background: Wound healing is among the frequent illnesses that affects the skin, and therefore, the screening of natural preparation to treat skin burn is important. In Morocco, Cynara humilis is a Moroccan medicinal plant widely used for the treatment of skin burn.

Objectives: The aim of this study was to investigate the safety of C.

The impact of the COVID-19 pandemic on the continuity of transfusion care for thallasemic patients: a case report.

The COVID-19 pandemic could have a major impact on the capacity of health systems to continue the delivery of essential health service. While health systems around the world are being challenged by increasing demand for care of COVID-19 patients, it is critical to maintain preventive and curative services, especially for the most vulnerable populations such people living with chronic conditions like thallasemics. In this context and since the start of the SARS-CoV-2 health crisis, the National Blood Transfusion Center of Morocco has ranked among its priorities the need to maintain transfusion management for chronic polytransfused patients, particularly those with thalassemia.

Immature platelets: a review of the available evidence.

Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets to the total number of platelets.

[Profile of Von Willebrand factor antigen in pregnancy: descriptive study of 390 pregnant women in Morocco].

Von Willebrand factor (vWF) is a glycoprotein which plays an important role in hemostasis. Its quantitative or qualitative deficit results in von Willebrand's disease (vWD). The study aims to update the current understanding of the distribution of vWF rates in Moroccan pregnant women and their variability in function of the ABO blood group.

Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces).

Introduction: Numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy.

Establishment of the hematology reference intervals in a healthy population of adults in the Northwest of Morocco (Tangier-Tetouan region).

Introduction: Among the most useful biological examinations in common medical practice, blood count is the most prescribed. The reference intervals of the hematological parameters of this examination are of major importance for clinical orientations and therapeutic decisions. In Morocco, the reference values used by the laboratories of medical biology and used by doctors are ones collected from Caucasian and European individuals.

In Vitro and In Vivo Antioxidant and Anti-Hyperglycemic Activities of Moroccan Oat Cultivars.

Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, -hydroxybenzoic, caffeic, salicylic, syringic, sinapic, -coumaric and chlorogenic acids.

[Epidemiological profile of hemoglobinopathies: a cross-sectional and descriptive index case study].

Hemoglobinopathies are congenital disorders resultimg from hemoglobin abnormalities. Major forms are often severe, their management is difficult and associated with a great psychosocial impact on patients and their families. They are classified as rare diseases and are still insufficiently known by health professionals.

[Evaluation of hemogram in patients with homozygous sickle cell disease: about 87 cases].

Homozygous sickle cell disease is one of the most frequent haemoglobinopathies in Morocco. Sickle cell disease is characterized by a large clinical and biological expression variability which depends on modulating genetic and environmental factors. Clinical manifestation includes regenerative anemia whose severity may vary among individuals.

[Epidemiological, clinical, cytologic and immunophenotypic aspects of acute leukemia in children: the experience at the hematology laboratory of IBN SINA University Hospital Center].

The aim of this study was to describe epidemiological, cytologic and immunophenotypic aspects of acute leukemias (AL) in children diagnosed at IBN SINA University Hospital Center and to determine the concordance between cytology and immunophenotyping results. This is a cross-sectional study conducted in the hematology laboratory of IBN SINA University Hospital Center between June 2012 and May 2014. Among the 104 cases with diagnosed AL, 52% were boys with a sex-ratio H/F= 1.