CCL19-Positive Lymph Node Stromal Cells Govern the Onset of Inflammatory Arthritis via Tropomyosin Receptor Kinase.

Objective: The study objective was to assess the role of CCL19 lymph node stromal cells of the joint-draining popliteal lymph node (pLN) for the development of arthritis.

Methods: CCL19 lymph node stromal cells were spatiotemporally depleted for five days in the pLN before the onset of collagen-induced arthritis (CIA) using Ccl19-Cre × iDTR mice. In addition, therapeutic treatment with recombinant CCL19-immunoglobulin G (IgG), locally injected in the footpad, was used to confirm the results.

Alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation.

Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages the liver, heart, and brain. Alcohol also has strong immunoregulatory properties.

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.

Butyrophilins are surface receptors belonging to the immunoglobulin superfamily. While several members of the butyrophilin family have been implicated in the development of unconventional T cells, butyrophilin 2a2 (Btn2a2) has been shown to inhibit conventional T cell activation. Here, we demonstrate that in steady state, the primary source of Btn2a2 are thymic epithelial cells (TEC).

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function.

Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased megakaryocyte expansion across common autoimmune diseases was shown for RA, systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS).

Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System.

Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as well as reduced immune system function.

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis.

Gut microbial dysbiosis is associated with the development of autoimmune disease, but the mechanisms by which microbial dysbiosis affects the transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating autoimmunity to inflammation. Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice and humans and can be used to predict transition from autoimmunity to inflammatory arthritis.

Ethanol consumption inhibits T cell responses and the development of autoimmune arthritis.

Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (T) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties.

[POISONING BY PSYCHOPHARMACOLOGICAL DRUGS IN AZERBAIJAN: THE RESULTS OF 8-YEAR PROSPECTIVE OBSERVATION].

Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016.

[Myocardial Infarction and Stroke Among Railway Employees in Azerbaijan].

We studied the incidence of myocardial infarction (MI) and stroke in two groups of railway employees aged over 39 years including pensioners. The first (main) group included employees (n=15 671) responsible for movement of trains and exposed to `action of harmful occupational factors. The second (control) group included persons (n=19 132) who were not exposed to harmful occupational factors.

[Current characteristics of all-cause and circulatory disease mortality in the Azerbaijan Republic].

Aim: To prove the value of summary data from the State Statistics Commission to characterize of risk of death from circulatory system diseases (CSD).

Material And Methods: The official data of the State Statistics Commission of the Azerbaijan Republic, which are available at its website (www.stat.

A potential regulatory loop between Lin28B:miR‑212 in androgen-independent prostate cancer.

Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not well understood.

[Risk of myocardial infarction in out-patient treatment of patients with type 2 diabetes].

The aim of this study was the identification of risk of myocardial infarction in out-patient treatment of type 2 diabetes. The study was carried out on 340 patients with type 2 diabetes. The risk of ischemic disease was determined during 10 years by PROCAM program.

[Lipid metabolism disorders at the breast cancer patients receiving hormonotherapy].

The main purpose of this research was to study the impact of hormonotherapy on changes of the lipid metabolism in patients with breast cancer. 451 breast cancer patients were under investigation. Depending on the treatment method, all patients were divided into four groups.

[On prevention and treatment of arterial hypertension in patients with breast cancer, and undergoing hormonotherapy].

The main purpose of this research was to study an impact of hormonotherapy on changes of the arterial blood pressure in patients with breast cancer. Case histories of 135 patients with the breast cancer and accompanying arterial hypertension (AH) were investigated. According to prescription of hormonotherapy, all patients were divided into two groups.

[Significance of stress echocardiography in patients with angiographically intact coronary arteries].

With the aim of assessment of the significance of stress echocardiography in patients with unchanged coronary arteries we analyzed data from 75 patients in whom coronary angiography (CAG) detected no hemodynamically significant narrowing of coronary arteries. In 38 patients coronary syndrome X (CSX) was revealed. In the group of patients with CSX transient disturbances of local contractility were significantly more frequently observed compared with patients without CSX (52% compared with 21%, respectively).

Immunohistochemical and electron-microscopic characteristics of secretory cardiomyocytes in experimental myocardial infarction.

Objective: To study immunohistochemical and electron-microscopic features of secretory cardiomyocytes in experimental myocardial infarction (MI).

Methods: Totally 15 hearts of dogs with experimental MI were studied. For electron-microscopic study materials were collected from left atrium, and its several parts (appendix, lateral and frontal walls).

[Efficacy of combined use of fosinopril and propranolol in acute myocardial infarction].

Echocardiography, Doppler echocardiography and ECG mapping were used in 40 patients aged 30-70 years with first anterior Q-wave myocardial infarction (MI) for the study of effects of combination of fosinopril and propranolol (20 patients) in comparison with propranolol alone (20 patients) on hemodynamics and size of myocardial damage. The use of fosinopril and propranolol was associated with lowering of systolic and diastolic blood pressure without development of hypotension, reduction of sum, number of leads with, and amplitude of ST-segment elevations, and improvement of parameters of left ventricular function. In propranolol treated patients favorable changes of all these parameters were less pronounced.

[Fungal myocarditis in deep visceral candidiasis].

Morphological and functional changes of the myocardium were studied in 40 patients with candidiasis and attempt to establish morphological criteria of fungal myocarditis was undertaken. Retrospective analysis of autopsy material showed that myocardial involvement in candidiasis was possible and was not as rare as it had been accepted. Clinical symptomatology was not always similar to that of classical infectious-allergic myocarditis.

[Classification of myocardial dystrophies in aviation medical certification].

Myocardial dystrophy is one of the most common noncoronary lesions of the myocardium in pilots. However, the abundance of proposed classifications of myocardial dystrophies poses certain problems to medical experts. The authors attempt to consider the existing classifications from the standpoint of aviation medical certification and advocate the most acceptable, to their thinking, systematics by N.

[The clinical characteristics of ischemic heart disease in patients with arterial hypertension of different origins].

To study the clinical picture of coronary heart disease with concomitant arterial hypertension of various genesis, 172 patients were examined, out of them the cause of arterial hypertension was hypertensive disease in 54, chronic pyelonephritis in 40, chronic glomerulonephritis in 37, and stenotic atherosclerosis of renal arteries in 29, endocrine disease in 12 patients. The patients were divided into 2 groups: (1) 148 with stenotic atherosclerosis of coronary arteries and (2) 24 patients with intact coronary arteries. Comparison of these patient groups revealed no clear-cut correlation between the age and the detection of exercise-induced angina, as well as the duration of arterial hypertension.