Effects of rotation speed and time, as solvent removal parameters, on the physico-chemical properties of prepared α-tocopherol nanoemulsions using solvent-displacement technique.

A bottom-up approach based on solvent-displacement technique was used to prepare α-tocopherol nanoemulsions. Effects of two main evaporation parameters namely, rotation speed (1 × 10-9 × 10 rpm) and rotation time (5-15 min) of utilized vacuum rotary evaporator, on the mean particle size, polydispersity index (PDI) and α-tocopherol degradation of the formed nanodroplets were evaluated using response surface methodology. Obtained results suggested three polynomial regression models for predicting the studied response variables' affected by selected evaporation parameters.