Publications by authors named "Azizbek A Azamatov"
Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure-Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico.
Azizbek A Azamatov Sherzod N Zhurakulov Valentina I Vinogradova Firuza Tursunkhodzhaeva Roaa M Khinkar
Molecules
January 2023
Article Synopsis
- Isoquinoline alkaloids are important for medicinal purposes, and methods to improve their safety and efficacy are crucial.
- A one-step synthesis of various tetrahydroisoquinolines was achieved with high yields using the Pictet-Spengler reaction, confirming the structures with advanced spectroscopic techniques.
- Toxicity studies on these compounds in mice revealed varying levels of toxicity, with some exhibiting promising local anesthetic activity while showing potential safety differences among the derivatives.