Publications by authors named "Azita Hajhosseini Talasaz"
Article Synopsis
- Warfarin therapy can lead to serious bleeding issues, even when patients are within the recommended INR range, and microRNAs may influence how patients respond to the medication through genetic regulation.
- This study examined the impact of specific genetic variations (SNPs) in the 3' untranslated region of certain genes on bleeding risk in 526 Iranian patients undergoing warfarin treatment.
- The findings suggest that the SNP rs12458 in the gene may lower the risk of bleeding complications for certain genotypes, indicating a need for further research to confirm these results for clinical applications.
Background: Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients.
Methods: A total of 552 warfarin treated patients who maintained on a target INR level of 2.
Findings on the association of NQO1 C609T polymorphism in the NQO1 gene and cardiovascular disease susceptibility are controversial. The objective of the current study was to examine the relationship between this polymorphism and the presence and severity of angiographically determined coronary artery disease (CAD). One-hundred and forty-five patients with newly diagnosed angiographically documented CAD (≥50 % luminal stenosis of any coronary vessel) as case group were compared to 139 controls (subjects with no luminal stenosis at coronary arteries).
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