E-Brachy: New dosimetry package for electronic brachytherapy sources.

Background: Large reported variability in the material composition and geometrical components of the Xoft electronic high-dose-rate brachytherapy Causes inter-source discrepancy in the source output. This variability is due to the manual manufacturing and assembly of the sources.

Purpose: This study aimed to develop a dosimetry software tool called E-Brachy to characterize the Xoft source and quantify the discrepancies in its photon spectrum and dosimetric properties.

Modeling the dynamics of cerebrovascular reactivity to carbon dioxide in fMRI under task and resting-state conditions.

Conventionally, cerebrovascular reactivity (CVR) is estimated as the amplitude of the hemodynamic response to vascular stimuli, most commonly carbon dioxide (CO). While the CVR amplitude has established clinical utility, the temporal characteristics of CVR (dCVR) have been increasingly explored and may yield even more pathology-sensitive parameters. This work is motivated by the current need to evaluate the feasibility of dCVR modeling in various experimental conditions.