Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders.

Background: Patients with bipolar disorder (BD) and major depressive disorder (MDD) often exhibit cognitive impairments, with choroid plexus (ChP) volume linked to these deficits and cortical structures. However, the relationship between ChP volume, cognition, and brain morphology in mood disorders remains understudied. This study aimed to investigate these mechanisms.

Surface-based analysis of early cortical gyrification and thickness alterations in treatment-Naïve, first-episode depressive patients during emerging adulthood.

Background: Extensive research, predominantly in adults, has highlighted structural brain variations among patients with major depressive disorder (MDD). However, emerging adults, who undergo significant cortical reshaping and are highly vulnerable to depression, receive relatively little attention, despite reporting a higher prevalence of childhood trauma experiences. This study examines cortical gyrification and thickness in emerging adults with first-episode, treatment-naïve MDD, with the objective of investigating their association with childhood trauma.