Amplitude and frequency changes in surface EMG of biceps femoris during five days Bruce Protocol treadmill test.

Electromyography (EMG) is one of the indirect tools in indexing fatigue. Fatigue can be detected when there are changes on amplitude and frequency. However, various outcomes from literature make researchers conclude that EMG is not a reliable tool to measure fatigue.

Effects of cytochrome p450 inhibitors on itraconazole and fluconazole induced cytotoxicity in hepatocytes.

Itraconazole and fluconazole have been reported to induce hepatotoxicity in patients. The present study was designed to investigate the role of cytochrome P450 inhibitors, SKF 525A, and curcumin pretreatment on the cytotoxicity of antifungal drugs fluconazole and itraconazole. For 3 consecutive days, female rats were administered daily SKF 525A or curcumin (5 and 25 mg/kg).