A superabsorbent and pH-responsive copolymer-hydrogel based on acemannan from Aloe vera (Aloe barbadensis M.): A smart material for drug delivery.

Combining natural polysaccharides with synthetic materials improves their functional properties which are essential for designing sustained-release drug delivery systems. In this context, the Aloe vera leaf mucilage/hydrogel (ALH) was reacted with acrylic acid (AA) to synthesize a copolymerized hydrogel, i.e.

Enhanced dye sequestration with natural polysaccharides-based hydrogels: A review.

Due to the expansion of industrial activities, the concentration of dyes in water has been increasing. The dire need to remove these pollutants from water has been heavily discussed. This study focuses on the reproducible and sustainable solution for wastewater treatment and dye annihilation challenges.

Chemical modification of Aloe vera leaf hydrogel for efficient cadmium-removal from spiked high-hardness groundwater.

Herein, the hydrogel from the leaf of the Aloe vera plant (ALH) was succinylated (SALH) and saponified (NaSALH). The FTIR, solid-state CP/MAS C NMR, and SEM-EDX spectroscopic analyses witnessed the formation of SALH and NaSALH from ALH. The pH for NaSALH was found to be 4.

A pH responsive and superporous biocomposite hydrogel of polysaccharide--methacrylic acid for intelligent drug delivery.

Herein, a drug delivery system (SSH--MAA) based on the mucilage from seeds of (SSH; polymer) and methacrylic acid (MAA; monomer) is introduced for the controlled delivery of venlafaxine HCl using a sustainable chemical approach. The optimized conditions for the designing of the ideal formulation (M4) of SSH--MAA were found to be 2.5% (w/w) of SSH, 30.

Pyrene-based covalent organic framework for selective enrichment of hydrophobic peptides with simultaneous proteins exclusion.

Owing to the desirable structures, covalent organic frameworks (COFs) have emerged as promising porous crystalline materials in bioanalytical and biomedical science. However, the application of their merits for analysis of hydrophobic peptides in complicated bio-samples has not been well investigated, possibly due to challenges in developing materials with high-specific binding effect of target peptides and accurate controllable pore-size for high selectivity. In this study, we proposed the size-exclusive peptide enrichment with Azo-COF constructed from 1,3,6,8-tetrabromopyrene (TBPy) building block and p-azoaniline linking units.

A Decision Support System for Face Sketch Synthesis Using Deep Learning and Artificial Intelligence.

The recent development in the area of IoT technologies is likely to be implemented extensively in the next decade. There is a great increase in the crime rate, and the handling officers are responsible for dealing with a broad range of cyber and Internet issues during investigation. IoT technologies are helpful in the identification of suspects, and few technologies are available that use IoT and deep learning together for face sketch synthesis.

TiO-modified fibrous core-shell mesoporous material to selectively enrich endogenous phosphopeptides with proteins exclusion prior to CE-MS analysis.

As an important post-translational modification of proteins, phosphorylation plays a key role in regulating a variety of complicated biological reactions. Owing to the fact that phosphopeptides are low abundant and the ionization efficiency could be suppressed in mass spectroscopic detection, highly efficient and selective enrichment methods are essential to identify protein phosphorylation by mass spectrometry. Here, we develop novel titanium oxide coated core shell mesoporous silica (CSMS@TiO) nanocomposites for enrichment of phosphopeptides with simultaneous exclusion of massive proteins.

Automatic Dissolution Testing with High-Temporal Resolution for Both Immediate-Release and Fixed-Combination Drug Tablets.

Dissolution testing plays many important roles throughout the pharmaceutical industry, from the research and development of drug products to the control and evaluation of drug quality. However, it is a challenging task to perform both high-efficient separation and high-temporal detection to achieve accurate dissolution profile of each active ingredient dissolved from a drug tablet. In our study, we report a novel non-manual-operation method for performing the automatic dissolution testing of drug tablets, by combining a program-controlled sequential analysis and high-speed capillary electrophoresis for efficient separation of active ingredients.

Capillary electrophoresis-immobilized enzyme microreactors for acetylcholinesterase assay with surface modification by highly-homogeneous microporous layer.

We propose a new capillary electrophoresis (CE)-based open-tubular immobilized enzyme microreactor (OT-IMER) and its application in acetylcholinesterase (AChE) assays. The IMER is fabricated at the capillary inlet (reactor length of ∼1 cm) with the inner surface modified by a micropore-structured layer (thickness of ∼220 nm, pore size of ∼15-20 nm). The use of IMER accomplishes the enzymatic reaction and separation/detection of the products in the same capillary within 3 min.

Core-shell silica microsphere-based trypsin nanoreactor for low molecular-weight proteome analysis.

Core-shell mesoporous silica (CSMS) microspheres with tunable mesopores in the shell are highly desired in various bioapplications. With novel CSMS microspheres that are synthesized using a convenient two-phase process, we report in this study the analysis of low molecular-weight (MW < 30 kDa) proteins by combining size-exclusion separation and enzyme immobilization. The obtained CSMS microspheres possess uniform diameter (1.