Comparison between sex and polymorphisms on FKBP5: perception of quality of life in non-syndromic patients. A cross-sectional study.

This study aimed to compare factors that influence perception of quality of life (QoL) in patients scheduled for orthognathic surgery. This was a cross-sectional study with 91 participants from two universities in Curitiba. The orthognathic quality of life questionnaire (OQLQ) was used to assess patients' perceptions of their QoL.

Genetic polymorphisms are involved in oral health-related quality of life in skeletal class III patients submitted to orthognathic surgery.

Objective: This study aimed to evaluate whether sex and genetic polymorphisms impact the oral health-related quality of life (OHRQoL) preoperatively and the difference between preoperative and postoperative OHRQoL in skeletal Class III patients submitted to orthognathic surgery.

Materials And Methods: This longitudinal study consisted of ninety-nine patients with skeletal Class III malocclusion who required orthognathic surgery. The Oral Health Impact Profile-14 (OHIP-14) is a questionnaire used to assess the OHRQoL with a 5-point Likert-type scale, covering seven domains related to physical and psychosocial factors.

Prevalence of "Reversal Nystagmus" in Benign Paroxysmal Positional Vertigo.

Purpose: To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV).

Study Design: Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, canalithiasis type. Six trials of Dix-Hallpike testing were completed for each subject.

Optimizing Testing for BPPV - The Loaded Dix-Hallpike.

Objectives: Although the Dix-Hallpike testing is generally considered as the gold standard for the identification of the posterior canal benign paroxysmal positional vertigo (BPPV), we investigated a modification of the maneuver termed the "loaded Dix-Hallpike."

Study Design: Prospective randomized controlled trial.

Materials And Methods: Twenty-eight patients participated in this prospective study comparing the standard Dix-Hallpike (S-DH) to the loaded Dix-Hallpike (L-DH) test.

Round window plugging in the treatment of superior semicircular canal dehiscence.

Objectives/hypothesis: Objectives were to describe the use of round window plugging for superior semicircular canal dehiscence syndrome and review further recommendations regarding the procedure based on our experience and to compare results with recent literature on round window plugging.

Study Design: Retrospective case series.

Methods: Fourteen patients underwent round window plugging for superior semicircular canal dehiscence at our institution from 2012 to 2015.

Physiological mechanisms of onset adaptation and contralateral suppression of DPOAEs in the rat.

An investigation was undertaken to measure medial olivocochlear (MOC) reflexes in anesthetized rats before and after sectioning of the middle-ear muscles. Distortion product otoacoustic emission (DPOAE) magnitude and phase temporal responses were measured ipsilaterally to study MOC-mediated "DPOAE onset adaptation" and in the presence of a contralateral noise to study MOC-mediated contralateral "suppression" (terms as used by previous researchers). Distortion product otoacoustic emission onset adaptation and contralateral suppression had predictable changes in direction of magnitude and phase that were dependent on the input-output function.

Total relief of severe left ventricular outflow obstruction after spontaneous rupture of chordae tendineae in a patient with hypertrophic cardiomyopathy.

In hypertrophic cardiomyopathy (HCM), rupture of mitral chordae tendineae is infrequent and causes acute haemodynamic deterioration. A 38 year old male patient had chordae rupture leading to prolapse of both mitral leaflets and severe regurgitation, without change in symptomatic status. One year before, he had had mild mitral regurgitation and a resting left ventricle outflow tract of 105 mm Hg that disappeared in the present evaluation.

Olivocochlear neurons in the chinchilla: a retrograde fluorescent labelling study.

Although the chinchilla is widely used as a model for auditory research, little is known about the distribution and morphology of its olivocochlear neurons. Here, we report on the olivocochlear neurons projecting to one cochlea, as determined by single and double retrograde fluorescent tracer techniques. 10 adult chinchillas were anesthetized and given either unilateral or bilateral injections of a fluorescent tracer (either Fluoro-Gold or Fast Blue) into scala tympani or as a control, a unilateral injection into the middle ear cavity.

Noradrenergic and serotonergic projections to the superior olive: potential for modulation of olivocochlear neurons.

The distribution and density of noradrenergic (NA) and serotonergic (5-HT) varicosities in the superior olive (SO) and periolivary region (PO) and their relationship to olivocochlear neurons was studied. Antibodies against 5-HT and the NA precursor enzyme dopamine beta-hydroxylase were utilized to examine the density of innervation of SO and PO. To determine the relationship of these varicosities to efferent neurons projecting to the cochlea, olivocochlear neurons were retrogradely labeled with biotinylated dextranamine (BDA).

Inferior colliculus stimulation and changes in 2f1-f2 distortion product otoacoustic emissions in the rat.

The external, central and dorsal subnuclei of the inferior colliculus (ICX, ICC, ICD respectively) have different patterns of descending projections to the periolivary region. We found that electrical stimulation of these subnuclei in anesthetized rats causes suppression of 2f1-f2 distortion product otoacoustic emissions (DPOAE). The responses in DPOAEs to stimulation of ICX and ICC are characterized by a large (7-25 dB), initial suppression which lasted 25-30 s (early phase) followed by a sustained smaller (3-15 dB) suppression (late phase).