Publications by authors named "Azeez Fashina"
Article Synopsis
- The study investigates damaging mutations in the human genome that may contribute to nonsyndromic cleft lip with or without cleft palate (nsCL ± P), focusing on high-impact mutations in African and Brazilian cohorts.* -
- Researchers utilized next-generation sequencing (NGS) and whole-exome sequencing to identify pathogenic variants and discovered several damaging mutations in a gene related to cell adhesion, which has a link to cleft palate in mice.* -
- The findings highlight the significance of the gene encoding AFADIN in the risk for nsCL ± P in humans and emphasize the effectiveness of combining NGS with computational analysis to better understand this condition's genetic basis.*
Background: Several population-based case-control studies have reported concurrent presentation of cancer and congenital malformations. Many associations have been made between oral clefting and cancers, though some of these results are conflicting. Some studies have reported an increased risk of cancer among 1st-degree relatives of cleft cases and vice versa, and also an excess risk of cancers of the breast, lung, and brain among those with oral clefts.
View Article and Find Full Text PDFObjective: Nonsyndromic cleft lip and/or cleft palate (NSCL/P) have multifactorial etiology where genetic factors, gene-environment interactions, stochastic factors, gene-gene interactions, and parent-of-origin effects (POEs) play cardinal roles. POEs arise when the parental origin of alleles differentially impacts the phenotype of the offspring. The aim of this study was to identify POEs that can increase risk for NSCL/P in humans using a genome-wide dataset.
View Article and Find Full Text PDFObjectives: To examine the literature and synthesize the available reports for the best possible option between absorbable, nonabsorbable, and tissue adhesives in cleft lip skin closure.
Design: We conducted systematic searches for randomized controlled trials and controlled clinical trials in PubMed, Cochrane, Ovid Medline, and OpenGrey databases. Identified studies were retrieved and assessed for eligibility.
Purpose: We evaluated the presence and level of psychological distress in patients before and after resection of benign orofacial tumors and identified the variables associated with this psychological distress.
Materials And Methods: The present study used the Hospital Anxiety and Depression Scale and the Rosenberg Self-Esteem Scale. A questionnaire that included these 2 scales was administered to the patients before surgery and at 1, 2, and 6 weeks after surgery.
Objective: To report the experience of wrong-site tooth extraction among Nigerian dentists.
Study Design: A self-administered questionnaire was distributed among a cross-section of Nigerian dentists. Information requested included personal experience on wrong-site tooth/teeth extraction and its after-effect, possible reasons for wrong-site tooth extraction and documentation of the event in patients' case.